Abstract reward and punishment representations in the human orbitofrontal cortex
Abstract reward and punishment representations in the human orbitofrontal cortex
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DOI：
10.1038/82959
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发表时间：
2001-01-01
影响因子：
25
通讯作者：
Andrews, C
中科院分区：
文献类型：
--
作者：
O'Doherty, J;Kringelbach, ML;Andrews, C
眼眶前额叶皮质(OFC)与情绪和情绪相关学习有关。使用事件相关功能磁共振成像(FMRI)，我们测量了进行情绪相关视觉反转学习任务的受试者的大脑激活情况，在这项任务中，选择正确的刺激会带来概率上确定的“金钱”回报，而选择不正确的刺激会导致金钱损失。OFC的不同领域被金钱奖励和惩罚所激活。此外，在这些区域，我们发现大脑活动的大小与受到的奖惩大小之间存在相关性。这些发现表明，人类眼眶额叶皮质的一种情感参与是它代表了抽象奖惩的程度，如收受或损失金钱。
The orbitofrontal cortex (OFC) is implicated in emotion and emotion-related learning. Using event-related functional magnetic resonance imaging (fMRI), we measured brain activation in human subjects doing an emotion-related visual reversal-learning task in which choice of the correct stimulus led to a probabilistically determined 'monetary' reward and choice of the incorrect stimulus led to a monetary loss. Distinct areas of the OFC were activated by monetary rewards and punishments. Moreover, in these areas, we found a correlation between the magnitude of the brain activation and the magnitude of the rewards and punishments received. These findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money.