E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia.
E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia.
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DOI：
10.3389/fimmu.2022.885144
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
T Lymphocyte Acute Lymphoblastic Leukemia (ALL) is an aggressive disease arising from transformation of T lymphocytes during their development. The mutation spectrum of T-ALL has revealed critical regulators of the growth and differentiation of normal and leukemic T lymphocytes. Approximately, 60% of T-ALLs show aberrant expression of the hematopoietic stem cell-associated helix-loop-helix transcription factors TAL1 and LYL1. TAL1 and LYL1 function in multiprotein complexes that regulate gene expression in T-ALL but they also antagonize the function of the E protein homodimers that are critical regulators of T cell development. Mice lacking E2A, or ectopically expressing TAL1, LYL1, or other inhibitors of E protein function in T cell progenitors, also succumb to an aggressive T-ALL-like disease highlighting that E proteins promote T cell development and suppress leukemogenesis. In this review, we discuss the role of E2A in T cell development and how alterations in E protein function underlie leukemogenesis. We focus on the role of TAL1 and LYL1 and the genes that are dysregulated in E2a-/- T cell progenitors that contribute to human T-ALL. These studies reveal novel mechanisms of transformation and provide insights into potential therapeutic targets for intervention in this disease.
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影响因子：
32.4
作者：
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通讯作者：
Kee, Barbara L.
影响因子：
20.3
作者：
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通讯作者：
Pear, Warren S.
影响因子：
15.3
作者：
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通讯作者：
VANDONGEN, JJM
影响因子：
11.4
作者：
BROWN, L;CHENG, JT;BAER, R
通讯作者：
BAER, R
影响因子：
30.5
作者：
De Obaldia, Maria Elena;Bell, J. Jeremiah;Wang, Xinxin;Harly, Christelle;Yashiro-Ohtani, Yumi;DeLong, Jonathan H.;Zlotoff, Daniel A.;Sultana, Dil Afroz;Pear, Warren S.;Bhandoola, Avinash
通讯作者：
Bhandoola, Avinash