Clinical Correlate of Brain SPECT Perfusion Abnormalities in Fibromyalgia
Clinical Correlate of Brain SPECT Perfusion Abnormalities in Fibromyalgia
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DOI：
10.2967/jnumed.108.053264
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发表时间：
2008-11-01
影响因子：
9.3
通讯作者：
Mundler, Olivier
中科院分区：
文献类型：
--
作者：
Guedj, Eric;Cammilleri, Serge;Mundler, Olivier
本研究的目的是探讨纤维肌痛患者脑SPECT灌注异常的具体临床相关性。方法：我们对20例纤维肌痛患者（P体素< 0.005）进行了基于全脑体素的相关分析，包括区域脑血流量和与疼痛（视觉模拟量表、图宾根疼痛行为量表和Douleur de Saint-Antoine量表）、残疾（纤维肌痛影响问卷[FIQ]）、焦虑和抑郁状态（医院焦虑和抑郁量表）相关的各种参数。10名健康对照女性也被纳入，以确定患者明显的低灌注和高灌注区域。结果：FIQ总分与双侧顶叶包括中枢后皮层灌注呈正相关。这些相关簇包括在显著高灌注区域。FIQ总分也与左前颞叶簇灌注呈负相关，包括明显低灌注区域。与局部脑血流无其他临床相关性。结论：纤维肌痛患者脑灌注异常与临床病情严重程度相关。
The purpose of this study was to investigate the specific clinical correlate of brain SPECT perfusion abnormalities reported in fibromyalgia. Methods: We performed a whole-brain voxel-based correlation analysis involving regional cerebral blood flow and various parameters related to pain (Visual Analog Scale, Tubingen Pain Behavior Scale, and Questionnaire Douleur de Saint-Antoine Scale), disability (Fibromyalgia Impact Questionnaire [FIQ]), and anxiety and depression status (Hospital Anxiety and Depression scale) in 20 patients with fibromyalgia (P voxel < 0.005). Ten healthy control women were also included, in order to determine areas of significant hypo- and hyperperfusions in patients. Results: FIQ total score was positively correlated with bilateral parietal perfusion, including postcentral cortex. These clusters of correlation were included in the areas of significant hyperperfusion. FIQ total score was also negatively correlated with perfusion of a left anterior temporal cluster, included in the areas of significant hypoperfusions. No other clinical correlation was observed with regional cerebral blood flow. Conclusion: These results show that brain perfusion abnormalities in patients with fibromyalgia are correlated with the clinical severity of the disease.