Investigating the Influence of Haemodynamic Stimuli on Intracranial Aneurysm Inception
Investigating the Influence of Haemodynamic Stimuli on Intracranial Aneurysm Inception
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DOI：
10.1007/s10439-013-0794-6
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发表时间：
2013-07-01
影响因子：
3.8
通讯作者：
Watton, Paul N.
中科院分区：
文献类型：
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作者：
Chen, Haoyu;Selimovic, Alisa;Watton, Paul N.
我们提出了一种新的方法来重建颅内动脉瘤（IA）形成前健康血管的假设几何形状：沿着动脉几何形状的离散化计算Frenet框架，用局部Frenet框架基向量表示动脉瘤段的上下游边界;然后，通过使用局部Frenet帧沿骨架传播闭合曲线沿着来重建假设的健康几何形状，使得上游边界平滑地变形为下游边界。该方法考虑了动脉血管系统的迂曲度，并且需要最小的用户主观性。该方法适用于22例描绘IA的临床病例。计算流体动力学模拟的血管没有IA进行和IA形成的位置的血液动力学刺激进行检查。我们观察到局部升高的壁剪切应力（WSS）和梯度振荡数（GON）与易受侧壁IA形成影响的区域高度相关（WSS为20/22，GON为19/22），而与WSS向量振荡相关的血流动力学指标相关性要低得多。
We propose a novel method to reconstruct the hypothetical geometry of the healthy vasculature prior to intracranial aneurysm (IA) formation: a Frenet frame is calculated along the skeletonization of the arterial geometry; upstream and downstream boundaries of the aneurysmal segment are expressed in terms of the local Frenet frame basis vectors; the hypothetical healthy geometry is then reconstructed by propagating a closed curve along the skeleton using the local Frenet frames so that the upstream boundary is smoothly morphed into the downstream boundary. This methodology takes into account the tortuosity of the arterial vasculature and requires minimal user subjectivity. The method is applied to 22 clinical cases depicting IAs. Computational fluid dynamic simulations of the vasculature without IA are performed and the haemodynamic stimuli in the location of IA formation are examined. We observe that locally elevated wall shear stress (WSS) and gradient oscillatory number (GON) are highly correlated (20/22 for WSS and 19/22 for GON) with regions susceptible to sidewall IA formation whilst haemodynamic indices associated with the oscillation of the WSS vectors have much lower correlations.