Sperm DNA damage and its role in IVF and ICSI.
Sperm DNA damage and its role in IVF and ICSI.
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DOI：
10.1186/s12610-016-0043-6
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发表时间：
2016
影响因子：
2.4
通讯作者：
Schlegel PN
中科院分区：
文献类型：
--
作者：
Bach PV;Schlegel PN
虽然传统上依靠精液分析来区分男性的生育能力和不育能力，但在当今辅助生殖技术时代，其效用受到质疑。对更复杂的诊断和预测工具的渴望导致精子 DNA 损伤在男性不育治疗中的使用增加。尽管有许多检测方法可以测量精子 DNA 损伤，但我们对精子 DNA 损伤的病因、测量和临床意义的理解仍然不完整。虽然目前的证据充满异质性，使比较和荟萃分析变得复杂，但在体外受精 (IVF) 和胞浆内单精子注射 (ICSI) 时代，精子 DNA 损伤似乎在妊娠的发育和维持中发挥着作用。然而，正如美国生殖医学会指出的那样，精子 DNA 损伤检测的常规和广泛使用尚未得到支持。需要进一步的研究来标准化精子 DNA 损伤的测量，并阐明精子 DNA 损伤在影响 IVF 和 ICSI 生殖结果的无数其他男性和女性因素中的确切作用。
While the semen analysis has traditionally been relied upon to differentiate fertile and infertile men, its utility has been questioned in the current era of assisted reproductive technologies. The desire for more sophisticated diagnostic and predictive tools has led to increased use of sperm DNA damage in the management of male infertility. Despite the availability of numerous assays to measure sperm DNA damage, our understanding of the etiology, measurement, and clinical implications of sperm DNA damage remains incomplete. While the current evidence is fraught with heterogeneity that complicates attempts at comparison and meta-analysis, there does appear to be a role for sperm DNA damage in the development and maintenance of pregnancy in the era of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). However, as noted by the American Society for Reproductive Medicine, the routine and widespread use of sperm DNA damage testing is not yet supported. Further studies are needed to standardize the measurement of sperm DNA damage and to clarify the exact role of sperm DNA damage within the myriad of other male and female factors contributing to reproductive outcomes in IVF and ICSI.