Metabolomic profiling in blood from umbilical cords of low birth weight newborns.
Metabolomic profiling in blood from umbilical cords of low birth weight newborns.
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DOI：
10.1186/1479-5876-10-142
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发表时间：
2012-07-09
影响因子：
7.4
通讯作者：
Lurbe E
中科院分区：
文献类型：
--
作者：
Ivorra C;García-Vicent C;Chaves FJ;Monleón D;Morales JM;Lurbe E
低出生体重与成年后患肥胖症、2型糖尿病和高血压的风险增加有关，尽管这种关联的机制还不清楚。目的是确定低出生体重和正常出生体重新生儿的脐带血浆代谢谱是否不同。选择50名健康孕妇及其婴儿。合格标准是足月出生和正常妊娠。根据出生体重对婴儿进行分组：低出生体重（LBW，出生体重<第10百分位数，n = 20）和对照组（对照组，出生体重在第75 - 90百分位数之间，n = 30）。使用核磁共振（NMR）生成脐带血浆样本的代谢指纹。同时，对母体的代谢组学特征进行了分析。所得数据进行化学计量学，主成分和偏最小二乘判别分析。来自LBW和对照新生儿的脐带血浆显示出明显不同的代谢特征。鉴定出7种代谢物，可将LBW与对照组区分开来。LBW新生儿血浆胆碱、脯氨酸、谷氨酰胺、丙氨酸和葡萄糖水平低于对照组，而苯丙氨酸和瓜氨酸水平高于对照组（p < 0.05）。两组母亲之间没有显着差异。低出生体重的新生儿显示出与正常出生体重的新生儿不同的代谢组学特征，这一发现在母亲中不存在。这些发现作为风险生物标志物的意义和潜在效用需要在未来的研究中得到解决。
Low birth weight has been linked to an increased risk to develop obesity, type 2 diabetes, and hypertension in adult life, although the mechanisms underlying the association are not well understood. The objective was to determine whether the metabolomic profile of plasma from umbilical cord differs between low and normal birth weight newborns. Fifty healthy pregnant women and their infants were selected. The eligibility criteria were being born at term and having a normal pregnancy. Pairs were grouped according to their birth weight: low birth weight (LBW, birth weight < 10th percentile, n = 20) and control (control, birth weight between the 75th-90th percentiles, n = 30). Nuclear Magnetic Resonance (NMR) was used to generate metabolic fingerprints of umbilical cord plasma samples. Simultaneously, the metabolomic profiles of the mothers were analysed. The resulting data were subjected to chemometric, principal component and partial least squares discriminant analyses. Umbilical cord plasma from LBW and control newborns displayed a clearly differentiated metabolic profile. Seven metabolites were identified that discriminate the LBW from the control group. LBW newborns had lower levels of choline, proline, glutamine, alanine and glucose than did the control newborns, while plasma levels of phenylalanine and citrulline were higher in LBW newborns (p < 0.05). No significant differences were found between the two groups of mothers. Low birth weight newborns display a differential metabolomic profile than those of normal birth weight, a finding not present in the mothers. The meaning and the potential utility of the findings as biomarkers of risk need to be addressed in future studies.
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影响因子：
7.7
作者：
Krebs, M;Krssak, M;Roden, M
通讯作者：
Roden, M
影响因子：
37.8
作者：
Crispi, Fatima;Bijnens, Bart;Gratacos, Eduard
通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
Greally JM
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影响因子：
3.6
作者：
Lillycrop, Karen A.;Slater-Jefferies, Jo L.;Hanson, Mark A.;Godfrey, Keith M.;Jackson, Alan A.;Burdge, Graham C.
通讯作者：
Burdge, Graham C.
影响因子：
5.1
作者：
BALLARD, JL;NOVAK, KK;DRIVER, M
通讯作者：
DRIVER, M