Cerebellar function in children with and without dyslexia during single word processing
Cerebellar function in children with and without dyslexia during single word processing
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DOI：
10.1002/hbm.24792
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发表时间：
2019-10-09
影响因子：
4.8
通讯作者：
Eden, Guinevere F.
中科院分区：
文献类型：
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作者：
Ashburn, Sikoya M.;Flowers, D. Lynn;Eden, Guinevere F.
阅读障碍的小脑缺陷假说认为，小脑功能障碍是这种常见学习障碍中阅读困难的根本原因。本研究使用功能磁共振成像 (fMRI) 和单个文字处理任务来测试患有 (n = 23) 和不患有 (n = 23) 阅读障碍儿童的活动和连接性差异。当文字处理与注视进行比较时，我们发现对照组的小脑活动，但与旨在揭示阅读特定活动的主动基线任务相比时却没有发现。在患有阅读障碍的组中，这两种对比都没有小脑活动，并且与没有阅读障碍的儿童相比也没有差异。转向对照中的功能连接（FC），背景 FC（即，非特定于阅读）主要存在于小脑和枕颞叶皮层之间。在患有阅读障碍的组中，小脑和几个皮质区域之间存在背景 FC。当比较两组时，他们在种子区域右小腿 I 和三个左半球外侧裂周围目标区域之间的连接方面的背景 FC 有所不同。然而，两组中都没有针对文字处理的特定任务 FC，也没有组间差异。总之，这些结果并不支持阅读障碍儿童在阅读过程中小脑功能受到影响的理论。
The cerebellar deficit hypothesis of dyslexia posits that dysfunction of the cerebellum is the underlying cause for reading difficulties observed in this common learning disability. The present study used functional magnetic resonance imaging (fMRI) and a single word processing task to test for differences in activity and connectivity in children with (n = 23) and without (n = 23) dyslexia. We found cerebellar activity in the control group when word processing was compared to fixation, but not when it was compared to the active baseline task designed to reveal activity specific to reading. In the group with dyslexia there was no cerebellar activity for either contrasts and there were no differences when they were compared to children without dyslexia. Turning to functional connectivity (FC) in the controls, background FC (i.e., not specific to reading) was predominately found between the cerebellum and the occipitaltemporal cortex. In the group with dyslexia, there was background FC between the cerebellum and several cortical regions. When comparing the two groups, they differed in background FC in connections between the seed region right crus I and three left-hemisphere perisylvian target regions. However, there was no task-specific FC for word processing in either group and no between-group differences. Together the results do not support the theory that the cerebellum is affected functionally during reading in children with dyslexia.