Invited commentary: childhood acute lymphoblastic leukemia and allergies: biology or bias?
Invited commentary: childhood acute lymphoblastic leukemia and allergies: biology or bias?
复制标题
特邀评论：儿童急性淋巴细胞白血病和过敏：生物学还是偏见？
DOI：
10.1093/aje/kws265
复制
发表时间：
2012
影响因子：
5
通讯作者：
Spector,LoganG
中科院分区：
文献类型：
--
作者：
Linabery,AmyM;Spector,LoganG
先前的流行病学研究表明，个人特应性/过敏史（总体病史以及单独研究的哮喘、湿疹和花粉热病史）与儿童急性淋巴细胞白血病（ALL）之间存在负相关关系，并且具有一定的一致性；然而，在大多数这些研究中，暴露数据是通过母亲访谈收集的。现在，在本期杂志上的一项基于人群和基于记录的研究中（Am J Epidemiol. 2012;176(11):970–978），Chang 等人。报道称，不同病因时期过敏性疾病的风险增加，使前一种范式受到质疑。对基础生物学文献的回顾表明，所提出的机制支持正相关或负相关。鉴于这种模糊性，现在轮到流行病学来确定关联的方向了。
Previous epidemiologic studies have shown an inverse association between a personal history of atopy/allergies, both overall and among asthma, eczema, and hay fever investigated separately, and childhood acute lymphoblastic leukemia (ALL) with some consistency; however, in most of these studies, exposure data were collected by maternal interview. Now, in a population-based and records-based study in this issue of theJournal(Am J Epidemiol. 2012;176(11):970–978), Chang et al. report an increased risk for allergic conditions across different etiologic time periods, calling the former paradigm into doubt. A review of the basic biology literature shows that proposed mechanisms support either a positive or an inverse association. In light of this ambiguity, it is epidemiology's turn to determine the direction of association.