Copper-Catalyzed Regioselective Cascade Alkylation and Cyclocondensation of Quinoline N-Oxides with Diazo Esters: Direct Access to Conjugated π-Systems
Copper-Catalyzed Regioselective Cascade Alkylation and Cyclocondensation of Quinoline N-Oxides with Diazo Esters: Direct Access to Conjugated π-Systems
复制标题
铜催化的喹啉N-氧化物与重氮酸酯的区域选择性级联烷基化和环缩合：直接进入共轭π-体系
DOI：
10.1002/chem.201602493
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发表时间：
2016-09-01
影响因子：
4.3
通讯作者：
Samanta, Rajarshi
中科院分区：
文献类型：
--
作者：
Biswas, Aniruddha;Karmakar, Ujjwal;Samanta, Rajarshi
一种廉价的铜催化的级联区域选择性烷基化，然后环缩合喹啉N-氧化物与α-重氮酯已成功地实现，以提供含杂芳烃的共轭π-系统。所开发的方法简单、直接、经济，具有广泛的底物范围。探讨了铜催化剂在C-H键官能化和刘易斯酸促进的环化反应中的双重作用。
An inexpensive copper-catalyzed cascade regioselective alkylation, followed by cyclocondensation of quinoline N-oxides with alpha-diazo esters has been achieved successfully to provide heteroarene-containing conjugated pi-systems. The developed method is simple, straightforward, and economical with a broad range of substrate scope. The dual role of copper catalyst in the C-H bond functionalization and in Lewis acid-promoted cyclization was explored.