ANTIBODIES REACTIVE WITH HUMAN T-LYMPHOTROPIC RETROVIRUSES (HTLV-III) IN THE SERUM OF PATIENTS WITH AIDS
ANTIBODIES REACTIVE WITH HUMAN T-LYMPHOTROPIC RETROVIRUSES (HTLV-III) IN THE SERUM OF PATIENTS WITH AIDS
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DOI：
10.1126/science.6324345
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
GALLO, RC
中科院分区：
文献类型：
--
作者：
SARNGADHARAN, MG;POPOVIC, M;GALLO, RC
从48例获得性免疫缺陷综合征（AIDS）患者的培养细胞中分离出人类嗜T淋巴细胞逆转录病毒第3亚群的病毒，统称为HTLV-III [人类T细胞白血病-淋巴瘤病毒-III]。HTLV-III的生物学特性及其蛋白质的免疫学分析表明，该病毒是HTLV家族的成员，并且它与HTLV-II的关系比与HTLV-I的关系更密切。88%的艾滋病患者和79%的同性恋男性的血清样本（其症状和体征经常先于艾滋病），但异性恋受试者的血清样本< 1%，具有针对HTLV-III抗原的抗体反应性。主要的免疫反应似乎是针对p41，推定的包膜抗原的病毒。
Viruses of a 3rd subgroup of human T-lymphotropic retroviruses, collectively designated HTLV-III [human T cell leukemia-lymphoma virus-III], were isolated from cultured cells of 48 patients with acquired immunodeficiency syndrome (AIDS). The biological properties of HTLV-III and immunological analyses of its proteins show that this virus is a member of the HTLV family, and that it is more closely related to HTLV-II than to HTLV-I. Serum samples from 88% of patients with AIDS and from 79% of homosexual men with signs and symptoms that frequently precede AIDS, but from < 1% of heterosexual subjects, had antibodies reactive against antigens of HTLV-III. The major immune reactivity appeared to be directed against p41, the presumed envelope antigen of the virus.