Effect of activation of central nervous system serotonin 1A receptors on cardiorespiratory function.
Effect of activation of central nervous system serotonin 1A receptors on cardiorespiratory function.
复制标题
中枢神经系统血清素 1A 受体激活对心肺功能的影响。
DOI：
--
复制
发表时间：
1989
影响因子：
3.5
通讯作者：
K. Kellar
中科院分区：
文献类型：
--
作者：
R. Gillis;K. Hill;J. Kirby;J. Quest;P. Hamosh;W. Norman;K. Kellar
先前的研究表明，新型抗高血压药物乌拉地尔作用于猫的髓质腹侧表面，导致血压下降。此外，受体结合研究发现乌拉地尔对血清素1A受体具有较高的亲和力。这些结果表明，与 5-羟色胺 1A 受体结合的药物可能在延髓腹侧表面 (VSM) 发挥降血压作用。为了检验这一假设，我们评估了 8-羟基-2-(二-N-丙氨基)四氢化萘 (8-OH-DPAT)（激活血清素 1A 受体的原型药物）在局部应用于 VSM 后对心血管活动的影响。将 8-OH-DPAT 以 1 微克/侧的剂量双侧应用于 VSM 的中间区域，可使平均血压降低 60 +/- 7 mm Hg（P 小于 0.05），心率降低 26 +/- 4 次/分钟（P 小于 0.05）（n = 8）。呼吸频率增加（8 +/- 1 次呼吸/1 分钟）和潮气量减少（13 +/- 4 毫升）也发生。这些变化与每分钟呼吸量的显着增加有关（130 +/- 41 ml，P 小于 0.05）。通过将另一种对血清素 1A 受体具有高亲和力的药物（即 B695-40）应用于 VSM 的中间区域，产生了类似的心肺变化。以 100 微克/千克的剂量静脉注射 8-OH-DPAT 模拟了腹面应用该药物的心肺作用。（摘要截断为 250 字）
Previous studies indicate that the new antihypertensive drug, urapidil, acts at the ventral surface of the medulla in cats to produce a fall in blood pressure. In addition, urapidil was found in receptor binding studies to have a relatively high affinity for the serotonin 1A receptor. These results suggest that drugs which bind to the serotonin 1A receptor might exert hypotensive effects at the ventral surface of the medulla (VSM). To test this hypothesis, the effects of 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT), the prototype drug for activating serotonin 1A receptors, were evaluated for cardiovascular activity after local application to the VSM. 8-OH-DPAT applied bilaterally to the intermediate area of the VSM in a dose of 1 micrograms/side produced a decrease in mean blood pressure of 60 +/- 7 mm Hg (P less than .05) and a decrease in heart rate of 26 +/- 4 beats/min (P less than .05) (n = 8). Increases in respiratory rate (8 +/- 1 breaths/1 min) and decreases in tidal volume (13 +/- 4 ml) also occurred. These changes were associated with a significant increase in respiratory minute volume (130 +/- 41 ml, P less than .05). Similar cardiorespiratory changes were produced by application of another drug with high affinity for the serotonin 1A receptor, namely B695-40, to the intermediate area of the VSM. Intravenous administration of 8-OH-DPAT in a dose of 100 micrograms/kg mimicked the cardiorespiratory effects of ventral surface application of this agent.(ABSTRACT TRUNCATED AT 250 WORDS)