Palladium-catalyzed reaction of aryl halides with ureas
Palladium-catalyzed reaction of aryl halides with ureas
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DOI：
10.1016/s0040-4039(01)00716-x
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发表时间：
2001-06-25
影响因子：
1.8
通讯作者：
Beletskaya, IP
中科院分区：
文献类型：
--
作者：
Artamkina, GA;Sergeev, AG;Beletskaya, IP
介绍了一种钯催化尿素芳基化反应的新方法。在Pd(2)dba(2)存在下，尿素和苯基脲与二氧六环中p位含吸电子基团的芳基卤化物发生偶联反应。以CHCl3、Xantphos和Cs2CO3为碱，得到N，N‘-二芳基脲，产率为-92%。(C)2001爱思唯尔科学有限公司。保留所有权利。
A new method for the palladium-catalyzed arylation of ureas is described. The coupling reaction of urea and phenylurea with aryl halides containing electron-withdrawing groups in the p-position in dioxane in the presence of 0.5-1.0 mol% of Pd(2)dba(2). CHCl3, Xantphos and Cs2CO3 as a base gives N,N'-diarylureas in yields of 64-92%. (C) 2001 Elsevier Science Ltd. All rights reserved.