Nuclear mechanics in differentiation and development
Nuclear mechanics in differentiation and development
复制标题
DOI：
10.1016/j.ceb.2011.10.001
复制
发表时间：
2011-12-01
影响因子：
7.5
通讯作者：
Lecuit, Thomas
中科院分区：
文献类型：
--
作者：
Hampoelz, Bernhard;Lecuit, Thomas
细胞核是高等真核生物细胞内最坚硬的细胞器之一。它的机械性能由核纤层和染色质的贡献决定。它们一起允许核对施加的应力的粘弹性响应，其中层被认为表现为弹性壳，而核质作为主要的粘性材料。核力学在分化和发育过程中发生变化。改变的核力学反映但也可能影响染色质结构的全局重排，这发生在细胞将自己提交到不同的谱系中时。因此，很可能细胞核的机械特性显著有助于适当的分化。
The nucleus is by far one of the stiffest organelles within cells of higher eukaryotes. Its mechanical properties are determined by contributions from the nuclear lamina and chromatin. Together they allow a viscoelastic response of the nucleus to applied stresses, where the lamina is thought to behave as an elastic shell, while the nucleoplasm contributes as a largely viscous material. Nuclear mechanics changes during differentiation and development. Altered nuclear mechanics reflects but might also influence global re-arrangements in chromatin architecture, which take place when cells commit themselves into distinct lineages. Thus it is likely that the mechanical characteristics of nuclei significantly contribute to proper differentiation.