Changes in T-lymphocyte subsets during acute rheumatic fever.
Changes in T-lymphocyte subsets during acute rheumatic fever.
复制标题
急性风湿热期间 T 淋巴细胞亚群的变化。
DOI：
10.1007/bf00915218
复制
发表时间：
1982
影响因子：
9.1
通讯作者：
Sharma,KB
中科院分区：
文献类型：
--
作者：
WilliamsJr,RC;Raizada,V;Prakash,K;vandeRijn,I;Zabriskie,JB;Stobo,JD;Sharma,KB
Relative proportions and numbers of helper [OKT4(+)] and suppressor [OKT8(+)] peripheral blood lymphocytes were examined in 32 young patients during the acute phase of rheumatic fever. No significant decrease in percentage T cells during acute rheumatic fever was noted in comparison to normal children controls from the same population. A decrease in absolute numbers of OKT4(+) T cells was also noted in acute rheumatic subjects not receiving corticosteroids (P<0.05). In addition, a significant decrease was documented in both proportions and total numbers of OKT8(+) putative suppressor cells during acute rheumatic attacks. C-reactive protein binding to T-lymphocyte subsets showed no preferential reactivityin vivofor suppressor or helper T cells. Antigen-reactive T lymphocytes identified with the T29 mouse hybridoma reagent showed similar proportions and numbers in rheumatic children as were noted in controls. The present data indicate profound alterations in both helper- and suppressor-cell types in the peripheral blood profile of children with acute rheumatic fever.
