Human allergy and geohelminth infections: a review of the literature and a proposed conceptual model to guide the investigation of possible causal associations
Human allergy and geohelminth infections: a review of the literature and a proposed conceptual model to guide the investigation of possible causal associations
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DOI：
10.1093/bmb/ldl015
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发表时间：
2006-01-01
影响因子：
6.7
通讯作者：
Rodrigues, L. C.
中科院分区：
文献类型：
--
作者：
Cooper, P. J.;Barreto, M. L.;Rodrigues, L. C.
地蚯蚓感染和过敏性疾病是主要的公共卫生问题，有证据表明，在发展中国家，它们是相互关联的。虽然有大量文献表明地蚯蚓感染与过敏之间的关系，但对于两者之间是否存在因果关系，以及如果存在因果关系，地蚯蚓感染是否会增加或减少过敏风险，人们几乎没有共识。对流行病学研究中相互矛盾的发现的一种解释是，地蚯蚓降低了高感染率地区的过敏风险，而增加了低感染率地区的过敏风险。慢性地虫病感染与过敏呈负相关，驱虫药治疗可能会增加过敏的患病率。本文就地蚓与过敏关系的研究进展进行综述；讨论地蚯蚓感染的流行和时间的相关性，并提出一个概念模型，以定义未来人类和动物研究中的相关科学问题。
Geohelminth infections and allergic disease are major public health problems and there is evidence in developing countries that they are associated. Although there is an extensive literature of the relationship between geohelminth infections and allergy, there is little consensus on whether the association is causal and if so, whether geohelminth infections may increase or decrease the risk of allergy. An explanation for the conflicting findings of epidemiological studies is that geohelminths decrease the risk of allergy in areas of high infection prevalence and increase the risk of allergy in areas of low prevalence. Chronic geohelminth infections are inversely associated with allergy and anthelmintic treatment may increase the prevalence of allergy. In this paper, we review studies that have investigated the relationship between geohelminths and allergy; discuss the relevance of prevalence and timing of geohelminth infections and propose a conceptual model to define relevant scientific questions in future human and animal studies.