Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis
Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis
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DOI：
10.1359/jbmr.060314
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发表时间：
2006-06-01
影响因子：
6.2
通讯作者：
Eriksen, Erik Fink
中科院分区：
文献类型：
--
作者：
Ma, Yanfei L.;Zeng, Qingqiang;Eriksen, Erik Fink
对55名接受特立帕肽或安慰剂治疗12-24个月的妇女进行经髂骨活检。我们报告的直接证据表明，仅在特立帕肽治疗的患者中，静止表面的骨形成模型存在，特立帕肽治疗的重塑部位的骨形成高于安慰剂。
Transiliac bone biopsies were obtained from 55 women treated with teriparatide or placebo for 12-24 months. We report direct evidence that modeling bone formation at quiescent surfaces was present only in teriparatide-treated patients and bone formation at remodeling sites was higher with teriparatide than placebo.