Neuroimaging studies of serotonin gene polymorphisms: Exploring the interplay of genes, brain, and behavior
Neuroimaging studies of serotonin gene polymorphisms: Exploring the interplay of genes, brain, and behavior
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DOI：
10.3758/cabn.6.1.44
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发表时间：
2006-03-01
影响因子：
2.9
通讯作者：
Hariri, Ahmad R.
中科院分区：
文献类型：
--
作者：
Brown, Sarah M.;Hariri, Ahmad R.
由于它提供了在神经系统水平上研究信息处理的独特能力，功能性神经影像学是探索基因、大脑和行为之间关系的有力工具。最近，功能性神经影像学提供了戏剧性的例证，如何启动子多态性在人类5-羟色胺转运体基因，这一直是弱相关的情绪行为（如神经质和焦虑特质）的几个方面，是密切相关的参与神经系统，即杏仁核和亚膝前额叶皮层，有利于情绪信息处理。这篇综述将概述这些遗传对脑功能的影响已被探索的实验策略，并强调这种策略的有效性，以描绘生物学途径和机制，有助于脑功能的个体差异的出现，潜在的偏见行为和精神疾病的风险。
Because of the unique ability it provides to investigate information processing at the level of neural systems, functional neuroimaging is a powerful tool to explore the relationship between genes, brain, and behavior. Recently, functional neuroimaging has provided dramatic illustrations of how a promoter polymorphism in the human serotonin transporter gene, which has been weakly related to several dimensions of emotional behaviors (such as neuroticism and anxiety traits), is strongly related to the engagement of neural systems-namely, the amygdala and subgenual prefrontal cortex, subserving emotional information processing. This review will outline the experimental strategy by which these genetic effects on brain function have been explored and highlight the effectiveness of this strategy to delineate biological pathways and mechanisms contributing to the emergence of individual differences in brain function that potentially bias behavior and risk for psychiatric illness.