Flavonoids as antioxidants and developmental regulators: relative significance in plants and humans.
Flavonoids as antioxidants and developmental regulators: relative significance in plants and humans.
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DOI：
10.3390/ijms14023540
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发表时间：
2013-02-07
影响因子：
5.6
通讯作者：
Tattini M
中科院分区：
文献类型：
--
作者：
Brunetti C;Di Ferdinando M;Fini A;Pollastri S;Tattini M
苯丙烷类化合物，特别是黄酮类化合物，在植物对各种非生物胁迫的响应中起着主要的抗氧化作用。此外，类黄酮是生长素运动的有效内源性调节剂，因此表现为发育调节剂。黄酮类化合物能够控制单个器官和整个植物的发育;因此，有助于植物胁迫诱导的形态发生反应。黄酮类化合物作为人体活性氧自由基（ROS）清除剂的重要性最近受到质疑，因为血浆和大多数组织中的黄酮类化合物浓度太低，无法有效减少ROS。相反，类黄酮可能在哺乳动物中作为信号分子发挥关键作用，通过它们与广泛的蛋白激酶相互作用的能力，包括丝裂原活化蛋白激酶（MAPK），取代细胞生长和分化的关键步骤。在这里，我们讨论了黄酮类化合物作为还原剂和信号分子在植物和人类中的相对重要性。我们表明，结构特征赋予活性氧清除剂的能力，黄酮类化合物也需要有效地控制在真核细胞的发育过程。
Phenylpropanoids, particularly flavonoids have been recently suggested as playing primary antioxidant functions in the responses of plants to a wide range of abiotic stresses. Furthermore, flavonoids are effective endogenous regulators of auxin movement, thus behaving as developmental regulators. Flavonoids are capable of controlling the development of individual organs and the whole-plant; and, hence, to contribute to stress-induced morphogenic responses of plants. The significance of flavonoids as scavengers of reactive oxygen species (ROS) in humans has been recently questioned, based on the observation that the flavonoid concentration in plasma and most tissues is too low to effectively reduce ROS. Instead, flavonoids may play key roles as signaling molecules in mammals, through their ability to interact with a wide range of protein kinases, including mitogen-activated protein kinases (MAPK), that supersede key steps of cell growth and differentiation. Here we discuss about the relative significance of flavonoids as reducing agents and signaling molecules in plants and humans. We show that structural features conferring ROS-scavenger ability to flavonoids are also required to effectively control developmental processes in eukaryotic cells.
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影响因子：
4.2
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