Urinary excretion of enteral iohexol in rats with intestinal ischaemia. The influence of size of ischaemic area and duration of exposure to contrast medium.
Urinary excretion of enteral iohexol in rats with intestinal ischaemia. The influence of size of ischaemic area and duration of exposure to contrast medium.
复制标题
肠缺血大鼠肠内碘海醇的尿排泄。
DOI：
10.3109/00365528809090158
复制
发表时间：
1988
影响因子：
1.9
通讯作者：
A. Stordahl
中科院分区：
文献类型：
--
作者：
A. Stordahl
研究了经胃管灌注碘己醇对缺血肠段、单纯肠结扎和正常肠段大鼠尿排泄的影响。给大鼠注射3ml造影剂后，分别观察1、2、3、4、5、6、8 h。在每个观察期结束时进行x光片和血液和尿液检查。对比剂给药2小时后，肠缺血大鼠膀胱明显的x线片混浊。同时用x射线荧光技术测定了尿和血清中的高碘浓度。膀胱混浊和尿中碘含量的变化与缺血肠的长度成正比，而与肠内暴露于造影剂的时间长短无关。在肠段缺血15厘米和45厘米的动物中，总体平均尿碘水平分别约为正常对照的11倍和32倍。相比之下，45 cm缺血段大鼠的总体平均血清水平是正常人的16倍。并讨论了临床意义。
The urinary excretion of iohexol instilled via orogastric tube was evaluated in rats with ischaemic intestinal segments, simple bowel ligature, and normal bowel. The rats were observed for periods of 1, 2, 3, 4, 5, 6, and 8 h, respectively, after the instillation of 3 ml of contrast medium. Radiographs and blood and urine tests were taken at the end of each observation period. Distinct radiographic opacification of the urinary bladder of the rats with intestinal ischaemia was demonstrated already 2 h after the administration of contrast medium and onwards. Concurrently high iodine concentrations in the urine and serum were measured by an X-ray fluorescence technique. The bladder opacity and iodine levels in the urine varied in close proportion to the length of ischaemic bowel irrespective of the duration of enteric exposure to contrast medium. Overall mean urinary iodine levels were approximately 11 and 32 times that of normal controls in animals with ischaemic bowel segments of 15 and 45 cm, respectively. In comparison, the overall mean serum level in rats with 45-cm ischaemic segments was 16 times that of normals. The clinical implications are discussed.