PET-MRI synergy in molecular, functional and anatomical cancer imaging
PET-MRI synergy in molecular, functional and anatomical cancer imaging
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DOI：
10.1007/s00259-008-0829-7
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发表时间：
2008-08-01
影响因子：
9.1
通讯作者：
Lucignani, Giovanni
中科院分区：
文献类型：
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作者：
Lucignani, Giovanni
在PET-CT之后，PET-MRI扫描仪的开发标志着对提供精致形态细节的高灵敏度和高特异性生物医学图像的持续追求的另一个里程碑。为什么需要PET-MRI？首先，PET-CT尽管在常规临床实践中已得到广泛应用，但与PET-MRI相比有两个缺点：它不真正允许同时数据采集，并且使患者暴露在显着的辐射剂量下。其次，高分辨率、高对比度的软组织形态学成像、光谱学和功能成像都是只有MRI才能提供的功能。如果了解PET和MRI的不同作用、它们联合使用的价值（在融合或并行分析中）以及同时进行两种扫描的优点，则可能更容易理解PET-MRI的价值。开发PET-MRI扫描技术的艰苦努力终于取得了实际成果。看看这个领域最近发表的一些论文可能有助于我们关注这些概念。
In the wake of PET-CT, the development of PET-MRI scanners marks another milestone in the ongoing quest for high-sensitivity and high-specificity biomedical images offering exquisite morphological detail. But why the need for PET-MRI? First, PET-CT, although well established in routine clinical practice, has two disadvantages compared with PET-MRI: it does not really allow simultaneous data acquisition, and it exposes the patient to a significant radiation dose. Second, high-resolution, very high contrast morphological imaging of soft tissues, spectroscopy, and functional imaging are all features that only MRI offers. It may be easier to appreciate the value of PET-MRI if one understands the different roles of PET and MRI, the value of their combined use (in fusion or side-by-side analysis), and the advantages of performing both scans concurrently. The strenuous efforts to develop PET-MRI scanning technology are at last yielding tangible results. A look at some of the most recently published papers in this field may help us to get these concepts into focus.