Is uric acid a predictive factor for graft dysfunction in renal transplant recipients?
Is uric acid a predictive factor for graft dysfunction in renal transplant recipients?
复制标题
DOI：
10.1016/j.transproceed.2007.03.028
复制
发表时间：
2007-05-01
影响因子：
0.9
通讯作者：
Haberal, M.
中科院分区：
文献类型：
--
作者：
Akgul, A.;Bilgic, A.;Haberal, M.
高尿酸血症是肾移植受者的常见并发症，尿酸(UA)可能在肾功能障碍中起一定作用。本研究的目的是评价尿酸对肾移植受者慢性移植物肾病(CAN)的影响。133名研究对象包括34名女性和99名男性，总体平均年龄为34.7+/-9.9岁。他们在1998至2000年间接受了肾移植。分别于移植后1个月和3年随访期间每年测定血清尿酸水平。在移植后的第一个月，55.3%的受者有高尿酸血症(男性高尿酸血症7 mg/dL；女性高尿酸血症6 mg/dL)，但在移植后3年，84.6%的受试者有高尿酸血症(P<；.001)。31.5%的患者在移植后平均发病31.8+/-14.3个月时被诊断为CAN。其中52%的患者在移植后43.3+/-20.8个月内发生移植物衰竭。在CAN发生前记录UA水平。根据COX回归分析，尿酸水平与CAN之间没有相关性(P&gT；.05；相对危险度，1.082；95%可信区间[CI]0.91.3)。我们的结论是，受者的高尿酸血症患病率高于健康人，但在移植后的头3年内，尿酸水平并不影响CAN的发生。
Hyperuricemia is a common complication in renal transplant recipients, and uric acid (UA) may play a role in renal dysfunction. The aim of this study was to evaluate the effects of UA on chronic allograft nephropathy (CAN) in renal transplant recipients. The 133 study subjects included 34 women and 99 men of overall mean age of 34.7 +/- 9.9 years. They underwent renal transplantation between 1998 and 2000. Serum UA levels were measured in the first month after transplantation and then at yearly intervals throughout a 3-year follow-up. In the first month after transplantation, 55.3% of recipients had hyperuricemia (UA > 7 mg/dL in men; UA > 6 mg/dL in women), but, 3 years after transplantation, 84.6% of the subjects had that disorder (P < .001). CAN was diagnosed in 31.5% of the patients at a mean onset of 31.8 +/- 14.3 months after transplantation. Fifty-two percent of these individuals experienced graft failure within 43.3 +/- 20.8 months after transplantation. UA levels were recorded before the development of CAN. There was no association between UA levels and CAN according to a Cox regression analysis (P > .05; relative risk, 1.082; 95% confidence interval [CI] 0.9-1.3). We concluded that the prevalence of hyperuricemia was higher among recipients than in healthy individuals, but that the UA level did not affect the development of CAN during first 3 years after transplantation.