Giardia assemblage A infection and diarrhea in Bangladesh
Giardia assemblage A infection and diarrhea in Bangladesh
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DOI：
10.1086/498169
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发表时间：
2005-12-15
影响因子：
6.4
通讯作者：
Houpt, ER
中科院分区：
文献类型：
--
作者：
Haque, R;Roy, S;Houpt, ER
蓝氏贾第鞭毛虫是全球最普遍的人类肠道原生动物，但只有少数感染会导致腹泻。我们在这里测试了两个主要的G。蓝氏菌基因型，即集合A和B，在它们引起疾病的倾向上不同。为了确定集合体A或B感染与腹泻之间是否存在关联，2534名孟加拉国患者参加了一项病例对照研究。共322贾第虫感染进行了鉴定，并通过实时聚合酶链反应基因型测定。较高的优势比腹泻，观察集合A和A2感染，而较高的寄生虫DNA载量和较高的总体患病率，观察集合B感染。我们的研究结果表明，致病力和繁殖力的基因型差异可能有助于解释为什么不是每一个贾第虫感染的结果，疾病，但他们需要在发展中国家的其他城市人口得到证实。
Giardia lamblia is the most prevalent human intestinal protozoan worldwide, but only a minority of infections result in diarrhea. We tested here whether the 2 major G. lamblia genotypes, assemblages A and B, differ in their propensity to cause disease. To determine whether an association exists between infection with assemblage A or B and diarrhea, 2534 Bangladeshi patients were enrolled in a case-control study. A total of 322 Giardia infections were identified and assayed for genotype by real-time polymerase chain reaction. Higher odds ratios for diarrhea were observed for assemblage A and A2 infections, whereas higher parasite DNA loads and a higher overall prevalence were observed for assemblage B infections. Our findings indicate that genotypic differences in virulence and fecundity may help to explain why not every Giardia infection results in disease, but they need to be confirmed in other urban populations of the developing world.