A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the clinical course of gastric cancer: Imaging features of IgG4-related kidney disease
A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the clinical course of gastric cancer: Imaging features of IgG4-related kidney disease
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DOI：
10.1080/14397595.2016.1245238
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发表时间：
2019-05-04
影响因子：
2.2
通讯作者：
Kawano, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Horita, Shigeto;Fujii, Hiroshi;Kawano, Mitsuhiro
我们报告一位81岁男性免疫球蛋白g4相关疾病（IgG4-RD），表现为颌下腺、淋巴结、肺、肾、主动脉壁和前列腺病变并伴有胃癌。胃癌手术治疗治愈后，开始使用皮质类固醇治疗进行性肾功能下降。在开始类固醇治疗之前，氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描显示多个IgG4-RD病变，但未发现癌症转移。然而，由于胃癌复发，患者在开始皮质类固醇治疗3个月后死亡。本例中，igg4小管间质性肾炎的影像学特征在共存胃癌的临床过程中发生了显著变化。本病例的影像学特征可能为肾脏中IgG4病变的扩散模式提供线索。
We describe an 81-year-old man with immunoglobulin G4-related disease (IgG4-RD) presenting with submandibular gland, lymph node, lung, kidney, aortic wall, and prostate lesions with concomitant gastric cancer. After curative surgical treatment of the gastric cancer, corticosteroid therapy for progressively decreasing renal function was started. Before starting steroid therapy, fluorodeoxyglucose positron emission tomography-computed tomography revealed multiple lesions of IgG4-RD but no metastasis of the cancer. However, the patient died 3 months after initiation of corticosteroid therapy because of recurrence of the gastric cancer. In this case, the imaging features of IgG4-tubulointerstitial nephritis dramatically changed during the clinical course of co-existing gastric cancer. The imaging features of the present case may provide clues to the pattern of spread of IgG4 lesions in the kidney.