Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus
Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus
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咖啡酰三萜酯作为南蛇藤的潜在抗缺血性中风剂
DOI：
10.1021/acs.jnatprod.6b00314
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发表时间：
2016
影响因子：
5.1
通讯作者：
Zhao Wei-Min
中科院分区：
文献类型：
--
作者：
Li Jin-Long;Wu Lei;Wu Jian;Feng Hong-Xuan;Wang Hong-Min;Fu Yan;Zhang Ru-Jun;Zhang Hai-Yan;Zhao Wei-Min
从南蛇藤（Celastrus orbiculatus）根皮中分得3个新的三萜化合物，分别为南蛇藤素A-C（1-3）和3-O-咖啡酰-α-香树脂醇（4）。通过光谱分析、Cu Kα射线X射线晶体学以及与文献报道的光谱数据的比较确定了它们的结构。体外生物活性实验表明，咖啡酰三萜酯1、3和4对氧糖剥夺（OGD）诱导的SH-SY 5 Y细胞损伤具有神经保护作用。进一步的动物研究表明，使用10 mg/kg（i. v.）次给药结束
Three new triterpenoids, celastrusins A–C (1–3), together with 3-O-caffeoyl-α-amyrin (4) were isolated from the root bark ofCelastrus orbiculatus. Their structures were identified by spectroscopic analysis, X-ray crystallography using Cu Kα radiation, and the comparison of both observed and reported spectroscopic data. An in vitro bioassay revealed that the caffeoyl triterpenoid esters1,3, and4possess neuroprotective effects against oxygen-glucose deprivation (OGD) induced SH-SY5Y cell damage. Further animal studies indicated that compound1significantly reduced brain infarction after transient middle cerebral artery occlusion (MCAO) in rats using a 10 mg/kg (i.v.) dose.