Gastric mucosal integrity:: gastric mucosal blood flow and microcirculation.: An overview
Gastric mucosal integrity:: gastric mucosal blood flow and microcirculation.: An overview
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DOI：
10.1016/s0928-4257(01)00015-8
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发表时间：
2001-01-01
影响因子：
--
通讯作者：
Mózsik, G
中科院分区：
文献类型：
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作者：
Abdel-Salam, OME;Czimmer, J;Mózsik, G
胃处于持续暴露于潜在危险物质的状态。盐酸与胃蛋白酶一起对胃粘膜构成主要和严重的威胁。含有胆汁和胰酶的碱性十二指肠内容物的回流是内源性的额外重要损伤因素。酒精、吸烟、药物，特别是阿司匹林和阿司匹林样药物，以及类固醇是可造成粘膜损伤的外源性粘膜刺激物。胃防御这些有害物质的能力归因于构成胃粘膜防御的许多因素。这些包括由表面上皮细胞分泌的粘液和碳酸氢盐、甘草素、巯基化合物和胃粘膜血流。一些研究人员认为后者在保护胃粘膜完整性方面至关重要。本文的目的是审查的实验和临床数据处理的作用，粘膜血流，特别是微循环损伤和保护胃粘膜。(C)2001爱思唯尔科技有限公司版权所有。
The stomach is in a state of continuous exposure to potentially hazardous agents. Hydrochloric acid together with pepsin constitutes a major and serious threat to the gastric mucosa. Reflux of alkaline duodenal contents containing bile and pancreatic enzymes arc additional important injurious factors of endogenous origin. Alcohol, cigarette smoking, drugs and particularly aspirin and aspirin-like drugs, and steriods are among exogenous mucosal irritants that can inflict mucosal injury. The ability of the stomach to defend itself against these noxious agents has been ascribed to a number of factors constituting the gastric mucosal defense. These include mucus and bicarbonate secreted by surface epithelial cells, prostaglandins, sulfhydryl compounds and gastric mucosal blood flow. The latter is considered by several researchers to be of paramount importance in maintainig gastric mucosal integrity. The aim of this paper is to review the experimental and clinical data dealing with the role of mucosal blood flow and in particular the microcirculation in both damage and protection of the gastric mucosa. (C) 2001 Elsevier Science Ltd. All rights reserved.