Hnpact of an increase in grading categories and double reporting on the reliability of breast cancer grade
Hnpact of an increase in grading categories and double reporting on the reliability of breast cancer grade
复制标题
DOI：
10.1111/j.1600-0463.2007.apm_560.x
复制
发表时间：
2007-04-01
期刊：
影响因子：
2.8
通讯作者：
Varghese, Rebecca
中科院分区：
文献类型：
--
作者：
Chowdhury, Nilotpal;Pal, Muktha R.;Varghese, Rebecca
目前的研究说明了使用综合总分（通过添加管状、核和有丝分裂评分以7分制获得）和双重报告对观察者之间的可靠性的影响。50张连续的乳腺癌切片由5位病理学家独立分级。通过二次加权kappa （k(w)）估计病理个体最终评分、总分和评分成分之间的观察者间信度。同样，对独立观察者对的双重报告分数（通过对两名独立病理学家的报告分数取平均值获得）的观察者间信度进行了估计。无论是对个别病理学家还是双重报告的分数，总分数给出的可靠性数字都高于最终分数。双报告总分和年级的信度也显著高于个体得分和年级（个体和双报告总分的平均k(w)分别=0.65和0.78）；个人和双报成绩分别为0.61和0.66)。因此，除了分级外，使用总分以及相同的双重报告显着增加了乳腺癌分级的观察者间可靠性。
The present study illustrates the effect of using the consolidated total score (obtained on a 7-point scale by adding the tubular, nuclear and mitotic scores) as well as double reporting on the inter-observer reliability of breast cancer grading by the Nottingham method. 50 consecutive breast cancer slides were graded independently by 5 pathologists. The interobserver reliability between the individual pathologists for final grade, total score and grade components was estimated by quadratic weighted kappa (k(w)). Similarly, the inter-observer reliability of double reported scores (obtained by averaging the reported scores of two independent pathologists) for independent observer pairs was estimated. The total scores gave higher reliability figures than the final grade both for individual pathologists and double reported scores. The double reported total scores and grade also gave significantly higher reliability figures than the individual scores and grade (average k(w) =0.65 and 0.78 for the individual and double reported total scores, respectively; 0.61 and 0.66 for the individual and double reported grades). Therefore, use of total scores in addition to grade its well as double reporting of the same significantly increases the interobserver reliability of breast cancer grading.