An Ion Source for the HVEE 14C Isotope Ratio Mass Spectrometer for Biomedical Applications
An Ion Source for the HVEE 14C Isotope Ratio Mass Spectrometer for Biomedical Applications
复制标题
DOI：
10.1017/s0033822200018154
复制
发表时间：
2008-04
期刊：
影响因子：
8.3
通讯作者：
D. Mous;W. Fokker;Rein Van Den Broek;R. Koopmans;C. Ramsey;R. Hedges
中科院分区：
文献类型：
--
作者：
D. Mous;W. Fokker;Rein Van Den Broek;R. Koopmans;C. Ramsey;R. Hedges
在过去的二十年里，加速器质谱（AMS）在地球科学和考古学的许多领域都有了重大的发展。在不久的将来，AMS应该在生物医学研究领域实现类似的潜力，最终导致临床应用。对于这些应用，所需的仪器与目前在14C测年领域中使用的仪器有很大不同。虽然所需的准确度和灵敏度比目前最先进的14C仪器的要求低一个数量级以上，但在生物医学研究中广泛接受14C AMS将需要体积小、操作简单且能够处理CO2样品的AMS光谱仪。为了满足这些需求，HVEE开发了一种专用于生物医学研究的紧凑型14C AMS光谱仪。该仪器由一个占地面积为2.25 × 1.25 m的紧凑型加速器和一个具有直接接受CO2和最佳用户友好性的离子源组成。前面已经描述了加速器的布局和设计，我们在这里讨论的加速器的进展，并提出的设计和第一个结果的CO2离子源。
During the past two decades, accelerator mass spectrometry (AMS) has allowed major developments in many areas of geosciences and archaeology. In the near future, AMS should realize a similar potential in the field of biomedical research, leading ultimately to clinical applications. For such applications, the required instrument differs significantly from that presently used in the field of 14C dating. Whereas the needed accuracy and sensitivity is more than an order of magnitude less demanding than that for present state-of-the-art 14C instrumentation, the widespread acceptance of 14C AMS in biomedical research will require AMS spectrometers that are small, simple to operate and capable of handling CO2 samples. In order to satisfy these demands, HVEE has developed a compact 14C AMS spectrometer dedicated to biomedical research. The instrument consists of a compact accelerator with a footprint of 2.25 × 1.25 m and an ion source that features direct CO2 acceptance and optimal user friendliness. Having previously described the layout and design of the accelerator, we here discuss progress on the accelerator and present the design and first results of the CO2 ion source.