Epidemiologic Survey of Japanese Patients with Idiopathic Pulmonary Fibrosis and Investigation of Ethnic Differences
Epidemiologic Survey of Japanese Patients with Idiopathic Pulmonary Fibrosis and Investigation of Ethnic Differences
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DOI：
10.1164/rccm.201403-0566oc
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发表时间：
2014-10-01
影响因子：
24.7
通讯作者：
Takahashi, Hiroki
中科院分区：
文献类型：
--
作者：
Natsuizaka, Motoki;Chiba, Hirofumi;Takahashi, Hiroki
依据：特发性肺纤维化（IPF）病因不明，预后不良。一些大规模的流行病学研究主要在西方国家进行。亚洲国家报道的研究很少。目前尚不清楚IPF是否存在种族差异。重要的是要确定亚洲人群目前的IPF状态，并将其与西方population.Objectives比较：为了提供日本IPF的流行病学状态，并调查种族差异。方法：我们选择北海道县（人口，560万）作为日本IPF的流行病学队列。根据2003年至2007年期间553例IPF患者的临床记录，我们进行了回顾性流行病学和预后分析。测量和主要结果：IPF的患病率和累积发病率分别为10.0/100，000和2.23/100，000，男性占72.7%，频率随年龄增加而增加。中位生存期为35个月，最常见（40%）的死亡原因是急性加重。影响IPF预后的最重要的因素是百分比vital capacity.Conclusions：IPF在日本人群中的地位是澄清第一次通过我们的研究。我们的研究结果表明，在男性中，急性加重导致的死亡率较高，而心血管疾病导致的死亡率较低，在日本比西方国家。这些结果可能表明IPF存在种族差异。
Rationale: Idiopathic pulmonary fibrosis (IPF) has an unknown etiology and poor prognosis. Several large-scale epidemiologic studies have been conducted predominantly in Western countries. There are few studies reported from Asian countries. It remains unclear whether ethnic difference exists in IPF. It is important to determine the current IPF status in Asian populations and compare it with that of Western populations.Objectives: To provide the epidemiologic status of IPF in Japan and to investigate ethnic differences.Methods: We selected Hokkaido prefecture (population, 5.6 million) as the epidemiologic cohort of IPF among Japanese. On the basis of the clinical records of 553 patients with IPF who were accepted based on the application of the Certificate of Medical Benefit between 2003 and 2007, we conducted a retrospective epidemiologic and prognostic analysis.Measurements and Main Results: The prevalence and cumulative incidence of IPF was 10.0 and 2.23 per 100,000 population, respectively, with 72.7% predominance of males and an increase in frequency with age. The median survival time was 35 months, and the most common (40%) cause of death was acute exacerbation. The most important factor influencing IPF prognosis was the percent vital capacity.Conclusions: The status of IPF in the Japanese population was clarified for the first time through our study. Our results showed that in men, the incidence of death caused by acute exacerbation was higher and that caused by cardiovascular disease was lower in Japan than in Western countries. These results may suggest ethnic differences in IPF.