Unconventional secretion: a stress on GRASP
Unconventional secretion: a stress on GRASP
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DOI：
10.1016/j.ceb.2011.04.005
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发表时间：
2011-08-01
影响因子：
7.5
通讯作者：
Rabouille, Catherine
中科院分区：
文献类型：
--
作者：
Giuliani, Fabrizio;Grieve, Adam;Rabouille, Catherine
大多数蛋白质遵循经典的分泌途径，从内质网，经高尔基体，到质膜或细胞外介质。然而，一些蛋白质通过两条替代路线到达这些最终目的地。一种支持胞外缺乏信号肽的细胞质蛋白的运输，另一种支持跨膜蛋白绕过高尔基体到质膜的运输。在这里，我们强调观察到的一些非常规分泌事件是由细胞应激触发的。此外，一种高尔基体蛋白，高尔基体重组和堆积蛋白(GRASP)，已被证明是这两种非常规分泌所必需的，我们讨论了它可能以不依赖高尔基体的方式支持这些事件的方式。
Most proteins follow the classical secretory pathway from the endoplasmic reticulum, via the Golgi, to the plasma membrane or extracellular medium. However, some proteins reach these final destinations by two alternative routes. One sustains the extracellular delivery of cytoplasmic proteins that lack a signal peptide, the other supports the transport of transmembrane proteins to the plasma membrane in a manner that bypasses the Golgi. Here, we highlight the observation that some unconventional secretion events are triggered by cellular stress. Furthermore, one Golgi protein, Golgi Re-Assembly and Stacking Protein (GRASP), has been shown to be essential to both types of unconventional secretion and we discuss ways in which it may support these events in a Golgi-independent manner.