A TOXIN FROM THE VENOM OF THE MARINE SNAIL CONUS-GEOGRAPHUS WHICH ACTS ON THE VERTEBRATE CENTRAL NERVOUS-SYSTEM
A TOXIN FROM THE VENOM OF THE MARINE SNAIL CONUS-GEOGRAPHUS WHICH ACTS ON THE VERTEBRATE CENTRAL NERVOUS-SYSTEM
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DOI：
10.1016/0041-0101(81)90106-9
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发表时间：
1981-01-01
期刊：
影响因子：
2.8
通讯作者：
CRUZ, LJ
中科院分区：
文献类型：
--
作者：
CLARK, C;OLIVERA, BM;CRUZ, LJ
来自海洋蜗牛 C. geographus 的毒液中的毒素被纯化至均质并进行了表征。该毒素是一种热稳定的酸性蛋白质，表观单体分子量为 13,000。它对小鼠腹膜内注射没有检测到毒性。注射，但脑内注射后有潜在的惊厥作用。它与毒液中作用于周围神经肌肉系统的其他毒素不同。
A toxin from the venom of the marine snail, C. geographus, was purified to homogeneity and characterized. The toxin was a heat stable acidic protein with an apparent monomer MW of 13,000. It had no detectable toxicity to mice on i.p. injection but was a potential convulsant following intracerebral injection. It was distinct from other toxins in the venom which acted on the peripheral neuromuscular system.