Smaller genetic risk in catabolic process explains lower energy expenditure, more athletic capability and higher prevalence of obesity in Africans.
Smaller genetic risk in catabolic process explains lower energy expenditure, more athletic capability and higher prevalence of obesity in Africans.
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分解代谢过程中较小的遗传风险解释了较低的能量消耗，更多的运动能力和肥胖症患病率较高。
DOI：
10.1371/journal.pone.0026027
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Xue C;Fu YX;Zhao Y;Gong Y;Liu X
非洲人体力活动的能量消耗（EE）低于欧洲人，这可能导致非洲人肥胖症的患病率较高，运动能力较强。但目前还不清楚为什么非洲人口中的EE较低。在这项研究中，我们试图探索非洲人EE较低的遗传机制。我们筛选了231种可能对分解代谢过程中的182个基因产生有害影响的常见变异。在群体水平上计算和分析筛选出的变异的遗传风险，包括突变总数和有害概率之和。人类群体遗传风险的结果表明，大多数非洲人（4个群体中的3个）在分解代谢过程中的遗传风险明显低于欧洲人和亚洲人，这可能导致非洲人产生能量的效率更高。在体育比赛中，运动员需要在短时间内消耗大量的能量，因此更高的能量产生效率可能有助于使非洲裔运动员更强大。另一方面，更高的能量产生效率也可能导致消耗更少的身体质量。因此，在相同或相似的条件下，非洲人可能比其他种族更容易肥胖。因此，分解代谢过程中较小的遗传风险可能是理解非洲人较低的EE，更多的运动能力和较高的肥胖患病率的核心。
Lower energy expenditure (EE) for physical activity was observed in Africans than in Europeans, which might contribute to the higher prevalence of obesity and more athletic capability in Africans. But it is still unclear why EE is lower among African populations. In this study we tried to explore the genetic mechanism underlying lower EE in Africans. We screened 231 common variants with possibly harmful impact on 182 genes in the catabolic process. The genetic risk, including the total number of mutations and the sum of harmful probabilities, was calculated and analyzed for the screened variants at a population level. Results of the genetic risk among human groups showed that most Africans (3 out of 4 groups) had a significantly smaller genetic risk in the catabolic process than Europeans and Asians, which might result in higher efficiency of generating energy among Africans. In sport competitions, athletes need massive amounts of energy expenditure in a short period of time, so higher efficiency of energy generation might help make African-descendent athletes more powerful. On the other hand, higher efficiency of generating energy might also result in consuming smaller volumes of body mass. As a result, Africans might be more vulnerable to obesity compared to the other races when under the same or similar conditions. Therefore, the smaller genetic risk in the catabolic process might be at the core of understanding lower EE, more athletic capability and higher prevalence of obesity in Africans.
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影响因子：
9.8
作者：
Price, Alkes L.;Kryukov, Gregory V.;Sunyaev, Shamil R.
通讯作者：
Sunyaev, Shamil R.
影响因子：
3.3
作者：
Xue, Cheng;Huang, Ren;Fu, Yun-Xin
通讯作者：
Fu, Yun-Xin
影响因子：
3.9
作者：
GEISSLER, CA;ALDOURI, MSH
通讯作者：
ALDOURI, MSH
影响因子：
7.1
作者：
DeLany, JP;Bray, GA;Volaufova, J
通讯作者：
Volaufova, J
DOI：
10.1097/med.0b013e3282c48a7c
发表时间：
2007-10-01
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Luke, Amy;Dugas, Lara;Kramer, Holly
通讯作者：
Kramer, Holly