Effects of pergolide on blood pressure and tissue injury in DOCA-salt hypertension.
Effects of pergolide on blood pressure and tissue injury in DOCA-salt hypertension.
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培高利特对 DOCA 盐高血压患者血压和组织损伤的影响。
DOI：
10.1080/08037050211266
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发表时间：
2002
期刊：
影响因子：
1.8
通讯作者：
Oyekan,Adebayo
中科院分区：
文献类型：
--
作者：
Newaz,MohammadA;Yousefipour,Zivar;Oyekan,Adebayo
本研究旨在评价DA-2受体激动剂培高利特对醋酸脱氧皮质酮（DOCA）盐性高血压的抗氧化作用及其在内源性内皮素1（ET-1）产生和器官肥大中的作用。将雄性Sprague-Dawley大鼠单肾切除（UNx）或单肾切除，并接受皮下植入DOCA并饮用1%氯化钠（DOCA）。将DOCA大鼠每天用培高利特（lmg/kg，i. p.）或维生素C（1 mg/大鼠，口服）。DOCA盐治疗使UNx大鼠的收缩压（SBP）从117 - 5 mmHg增加到162 - 10 mmHg（p < 0.05），增加了45 - 2 mmHg，培高利特和维生素C的作用减弱。DOCA大鼠的超氧化物生成没有增加;然而，培高利特和维生素C分别显著降低了49 - 7%和52 - 13%的超氧化物生成（p < 0.05）。与UNx大鼠相比，UNx大鼠的血浆ET-1水平增加两倍，但DOCA中降低至42 - 7%（p < 0.05）。培高利特和维生素C分别使血浆ET-1水平进一步降低43 - 10%（p < 0.05）和46 - 8%（p < 0.05）。培高利特可增加DOCA大鼠的尿Na+排泄，但未改变尿蛋白排泄或左心室和主动脉肥大。这些数据表明，培高利特降低DOCA盐性高血压患者的SBP可能归因于其利钠能力，而不是其减少超氧化物产生或ET-1产生的能力。
The present study was designed to evaluate the possible antioxidant effect of pergolide, a DA-2 receptor agonist, in deoxycorticosterone acetate (DOCA)-salt hypertension and its role in endogenous endothelin1 (ET-1) production and organ hypertrophy. Male Sprague-Dawley rats were uninephrectomized (UNx) or uninephrectomized, and received subcutaneous implants of DOCA and drank 1% sodium chloride (DOCA). DOCA rats were treated daily for 3 weeks with pergolide (1 mg/kg, i.p.) or vitamin C (1 mg/rat, orally). DOCA-salt treatment increased systolic blood pressure (SBP) in UNx rats by 45 - 2 mmHg from 117 - 5 to 162 - 10 mmHg ( p < 0.05), an effect blunted by pergolide and vitamin C. Superoxide generation was not increased in DOCA rats; however, both pergolide and vitamin C significantly reduced superoxide generation by 49 - 7% and 52 - 13%, respectively ( p < 0.05). Plasma ET-1 levels increased twofold in UNx rats but was reduced to 42 - 7% ( p < 0.05) in DOCA compared to UNx rats. Pergolide and vitamin C reduced plasma ET-1 levels further by 43 - 10% ( p < 0.05) and 46 - 8% ( p < 0.05), respectively. Pergolide increased urinary Na+ excretion but did not alter urinary protein excretion or the left ventricular and aortic hypertrophy in DOCA rats. These data suggest that the reduction of SBP by pergolide in DOCA-salt hypertension may be attributed to its natriuretic ability, not its ability to reduce superoxide generation or ET-1 production.