Resource competition as a mechanism for B cell homeostasis
Resource competition as a mechanism for B cell homeostasis
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DOI：
10.1073/pnas.94.11.5792
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发表时间：
1997-05-27
影响因子：
11.1
通讯作者：
Freitas, AA
中科院分区：
文献类型：
--
作者：
McLean, AR;Rosado, MM;Freitas, AA
细胞对生存信号的竞争为维持细胞稳态提供了一种令人信服的和吸引人的机制[Raff，M，C，（1992）Nature（伦敦）356，397-400]，我们提出了对资源竞争在外周B细胞数量调节中的作用的理论和实验研究。我们使用正式的生态竞争理论，种间竞争的数学模型和竞争性再增殖实验，以表明B细胞必须竞争才能在外周中持续存在，并且抗原形成B细胞竞争的资源的一部分。
Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M, C, (1992) Nature (London) 356, 397-400], We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers, We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.