The small nuclear RNAs of Drosophila.
The small nuclear RNAs of Drosophila.
复制标题
果蝇的小核 RNA。
DOI：
10.1016/0022-2836(84)90264-x
复制
发表时间：
1984
影响因子：
5.6
通讯作者：
Pederson,T
中科院分区：
文献类型：
--
作者：
Myslinski,E;Branlant,C;Wieben,ED;Pederson,T
We have investigated the sequences of the major small nuclear RNAs ofDrosophilacultured cells, with the objective of elucidating phylogenetically conserved primary and secondary structures by comparison of the data with previously determined sequences of these RNAs in vertebrate species. Our results reveal striking degrees of conservation between eachDrosophilaRNA and its vertebrate cognate, and also demonstrate blocks of homology among theDrosophilasmall nuclear RNAs, as previously described for vertebrates. The most conserved features include the 5′ terminal region of U1 RNA, thought to function in pre-mRNA splicing, most of the regions of U4 RNA recently implicated in 3′ processing of pre-mRNA, and the major snRNP protein binding site (“domain A”) that is also shared by vertebrate U1, U2, U4 and U5 RNAs. Several other conserved features have been revealed, suggesting additional regions of functional significance in these RNAs and also providing further insights into the evolutionary history of the small nuclear RNAs.
