INTRINSIC NERVES OF THE PANCREAS AFTER CELIAC AND SUPERIOR MESENTERIC GANGLIONECTOMY IN RATS - A MORPHOLOGICAL-STUDY OF ACETYLCHOLINESTERASE ACTIVITY AND CATECHOLAMINE HISTOFLUORESCENCE
INTRINSIC NERVES OF THE PANCREAS AFTER CELIAC AND SUPERIOR MESENTERIC GANGLIONECTOMY IN RATS - A MORPHOLOGICAL-STUDY OF ACETYLCHOLINESTERASE ACTIVITY AND CATECHOLAMINE HISTOFLUORESCENCE
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DOI：
10.1097/00006676-198709000-00013
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发表时间：
1987-01-01
期刊：
影响因子：
2.9
通讯作者：
ROZE, C
中科院分区：
文献类型：
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作者：
ANGLADE, P;MICHEL, C;ROZE, C
研究了腹腔和肠系膜上神经节切除术（GGX）对雄性Wistar大鼠胰腺内源性介入的影响。用组织化学方法对对照组和去神经节大鼠胰腺的神经元进行染色，证实乙酰胆甾醇酯酶（AChE）活性和儿茶酚胺诱导的荧光。研究了胰头的两个节段（“十二指肠”和“脾”节段）。对照组和去神经节大鼠脾节段的神经元细胞体表面密度均大于胰头十二指肠节段（p < 0.01）。对照组和去节大鼠神经元胞体表面密度和乙酰胆碱酯酶染色强度无显著差异。大多数疼痛阳性纤维在神经节切除术后存活；只有一些人消失了。这些消失的纤维与对照大鼠胰腺组织中发现的最薄的纤维束相对应。神经节切除术后，只有10%的儿茶酚胺纤维保留下来。一些剩余的纤维可能穿过直接的十二指肠胰通路。
The effect of surgical celiac and superior mesenteric ganglionectomy (GGX) on intrinsic pancreatic innervention was studied in male Wistar rats. Neurons were stained in the pancreas of control and ganglionectomized rats with histochemical methods evidencing the acetylcholiesterase (AChE) activity and the induced fluorescence of catecholamines. Two segments of the head of the pancreas ("duodenal" and "splenic" segments) were studied. The surface density of neuronal cell bodies was larger in the splenic segment than in the duodenal segment of the head of the pancreas (p < 0.01), both in control and in ganglionectomized rats. The surface density of the neuronal cell bodies and the intensity of AChE staining were not significantly different in control and in ganglionectomized rats. Most AChE-positive fibers survived after ganglionectomy; only some of them disappeared. These disappearinjg fibers corresponded to the thinnest fiber bundles found in the pancreatic tissue of control rats. Only 10% of catecholamine fibers remained after ganglionectomy. Some of the remaining fibers may run through direct duodenopancreatic pathways.