Multiple receptor subtypes mediate the effects of serotonin on rat subfornical organ neurons.
Multiple receptor subtypes mediate the effects of serotonin on rat subfornical organ neurons.
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多种受体亚型介导血清素对大鼠穹窿下器官神经元的影响。
DOI：
10.1152/ajpregu.1998.275.6.r2035
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Schmid,HA
中科院分区：
文献类型：
--
作者：
Scrogin,KE;Johnson,AK;Schmid,HA
The subfornical organ (SFO) receives significant serotonergic innervation. However, few reports have examined the functional effects of serotonin on SFO neurons. This study characterized the effects of serotonin on spontaneously firing SFO neurons in the rat brain slice. Of 31 neurons tested, 80% responded to serotonin (1–100 μM) with either an increase (n= 15) or decrease (n= 10) in spontaneous activity. Responses to serotonin were dose dependent and persisted after synaptic blockade. Excitatory responses could also be mimicked by the 5-hydroxytryptamine (5-HT)2A/2Creceptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI; 1–10 μM) and could be blocked by the 5-HT2A/2C-receptor antagonist LY-53,857 (10 μM). LY-53,857 unmasked inhibitory responses to serotonin in 56% of serotonin-excited cells tested. Serotonin-inhibited cells were also inhibited by the 5-HT1A-receptor agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT; 1–10 μM;n= 7). The data indicate that SFO neurons are responsive to serotonin via postsynaptic activation of multiple receptor subtypes. The results suggest that excitatory responses to serotonin are mediated by 5-HT2Aor 5-HT2Creceptors and that inhibitory responses may be mediated by 5-HT1Areceptors. In addition, similar percentages of serotonin-excited and -inhibited cells were also sensitive to ANG II. As such the functional relationship between serotonin and ANG II in the SFO remains unclear.
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降钙素对大鼠穹窿下器官 ANG II 反应性神经元活性的影响。
DOI：
--
发表时间：
1998
期刊：
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
影响因子：
--
作者：
H. Schmid;M. Rauch;J. Koch
通讯作者：
J. Koch
体外大鼠穹窿下器官的神经组织以及渗透压和吗啡受体假设的检验。
DOI：
--
发表时间：
1979
期刊：
Journal of Physiology
影响因子：
--
作者：
P. Buranarugsa;J. Hubbard
通讯作者：
J. Hubbard
上行血清素能系统参与刺激心房利钠肽释放。
DOI：
10.1073/pnas.91.25.12022
发表时间：
1994
影响因子：
11.1
作者：
Reis,LC;Ramalho,MJ;Favaretto,AL;Gutkowska,J;McCann,SM;Antunes-Rodrigues,J
通讯作者：
Antunes-Rodrigues,J
穹窿下器官的损伤影响麻醉大鼠对集中施用的松弛素的血压反应。
DOI：
10.1677/joe.0.1220747
发表时间：
1989
期刊：
The Journal of endocrinology
影响因子：
--
作者：
A. D. Mumford;L. J. Parry;A. Summerlee
通讯作者：
A. Summerlee
穹窿下器官中的单胺。
影响因子：
2.9
作者：
W. Lichtensteiger
通讯作者：
W. Lichtensteiger