Effects of reduced sodium intake on hypertension control in older individuals -: Results from the trial of nonpharmacologic interventions in the elderly (TONE)
Effects of reduced sodium intake on hypertension control in older individuals -: Results from the trial of nonpharmacologic interventions in the elderly (TONE)
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DOI：
10.1001/archinte.161.5.685
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发表时间：
2001-03-12
影响因子：
--
通讯作者：
Lacy, CR
中科院分区：
文献类型：
--
作者：
Appel, LJ;Espeland, MA;Lacy, CR
背景资料：很少有试验评估了老年人减少钠摄入量的影响，没有试验研究了相关亚组，如African American.Patients和方法的影响：钠减少对血压（BP）和高血压控制的影响进行了评估，在681例高血压患者，年龄在60至80岁，随机分配到一个减少钠干预或对照组。参与者（47%女性，23%非裔美国人）在服用1种抗高血压药物时收缩压低于145 mm Hg，舒张压低于85 mm Hg。干预开始后三个月，停药。主要终点为平均收缩压≥ 150 mm Hg、平均舒张压≥ 90 mm Hg、恢复用药或随访期间发生心血管事件（平均27.8个月）。结果：与对照组相比，低钠干预组平均尿钠排泄量减少40 mmol/d（P
Background: Few trials have evaluated the effects of reduced sodium intake in older individuals, and no trial has examined the effects in relevant subgroups such as African Americans.Patients And Methods: The effects of sodium reduction on blood pressure (BP) and hypertension control were evaluated in 681 patients with hypertension, aged 60 to 80 years, randomly assigned to a reduced sodium intervention or control group. Participants (47% women, 23% African Americans) had systolic BP less than 145 mm Hg and diastolic BP less than 85 mm Hg while taking 1 anti-hypertensive medication. Three months after the start of intervention, medication was withdrawn. The primary end point was occurrence of an average systolic BP of 150 mm Hg or more, an average diastolic BP of 90 mm Hg or more, the resumption of medication, or a cardiovascular event during follow-up (mean, 27.8 months).Results: Compared with control, mean urinary sodium excretion was 40 mmol/d less in the reduced sodium intervention group (P