A Role for Exercise to Counter Skeletal Muscle Clock Disruption.
A Role for Exercise to Counter Skeletal Muscle Clock Disruption.
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DOI：
10.1249/jes.0000000000000235
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发表时间：
2021-01
影响因子：
5.7
通讯作者：
Redman LM
中科院分区：
文献类型：
--
作者：
Erickson ML;Esser KA;Kraus WE;Buford TW;Redman LM
Disruption of the skeletal muscle circadian clock leads to a preferential shift towards lipid oxidation, while reducing carbohydrate oxidation. These effects are apparent at the whole-body level, including glucose intolerance, increased energy expenditure, and fasting hyperglycemia. We hypothesize that exercise counters these metabolic disturbances by modifying the skeletal muscle clock and reverting substrate metabolism back towards an optimal substrate balance. Exercise may mitigate cardiometabolic disease in part through actions on the skeletal muscle circadian clock.
