Current understanding of multiple risk factors as the metabolic syndrome: Distillation or deconstruction
Current understanding of multiple risk factors as the metabolic syndrome: Distillation or deconstruction
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DOI：
10.1055/s-2006-933314
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发表时间：
2006-02-01
影响因子：
2.7
通讯作者：
Boden-Albala, Bernadette
中科院分区：
文献类型：
--
作者：
Boden-Albala, Bernadette
“代谢综合征”是一个新的术语，它定义了血管危险因素的聚集，如高脂血症、肥胖、血压升高和血糖升高。关于该术语的使用存在争议，这提出了一个问题，即血管危险因素的独特分组是否比被视为独立但重要的实体的多个危险因素的叠加效应增加了更多的临床风险。无论答案如何，代谢综合征都构成了一个重大的公共卫生问题，美国有超过4700万人符合代谢综合征的标准。尽管研究表明代谢综合征是总体死亡率和心血管事件的危险因素，但代谢综合征与缺血性卒中之间的关系尚未得到很好的表征。两项大型横断面研究报告了代谢综合征与卒中史风险增加之间的相关性。一项大型多种族前瞻性研究发现，在调整社会人口统计学和其他心血管危险因素后，代谢综合征与缺血性卒中风险增加显著相关。这项研究估计代谢综合征可能占缺血性卒中的19%，包括30%的女性卒中和40%以上的西班牙裔卒中。尽管对其定义的效用存在争议，但有证据表明代谢综合征是缺血性卒中的重要危险因素，其影响因性别和种族而异。此外，代谢综合征具有重要的临床和公共卫生意义，有助于轻松识别血管事件风险最大的个体。
The "metabolic syndrome" is a new term that defines the clustering of vascular risk factors, such as hyperlipidemia, obesity, elevated blood pressure, and elevated blood glucose. Controversy exists regarding the use of the term, which raises the question of whether the unique grouping of vascular risk factors adds more clinical risk then the additive effect of multiple risk factors viewed as separate but important entities. Whatever the answer, the metabolic syndrome constitutes a major public health problem with over 47 million persons in the United States meeting criteria for the metabolic syndrome. Although studies have demonstrated that the metabolic syndrome is a risk factor for overall mortality as well as cardiovascular events, the relationship between the metabolic syndrome and ischemic stroke has not been well characterized. Two large cross-sectional studies report an association between metabolic syndrome and increased risk of a history of stroke. One large multiethnic prospective study found the metabolic syndrome to be significantly associated with an increased risk of ischemic stroke after adjustment for sociodemographics and other cardiovascular risk factors. This study estimated that the metabolic syndrome may account for 19% of ischemic strokes including 30% of stroke in women and over 40% of stroke in Hispanics. Despite debate about the utility of its definition, there is evidence to suggest that the metabolic syndrome is an important risk factor for ischemic stroke, with differential effects by gender and race-ethnicity. Further, the metabolic syndrome has important clinical and public health implications by helping to easily identify individuals at greatest risk of vascular events.