Five COX-2 gene polymorphisms and risk of breast cancer: an updated meta-analysis based on 19 case–control studies
Five COX-2 gene polymorphisms and risk of breast cancer: an updated meta-analysis based on 19 case–control studies
复制标题
五种 COX-2 基因多态性与乳腺癌风险：基于 19 项病例对照研究的更新荟萃分析
DOI：
10.1007/s12032-014-0397-6
复制
发表时间：
2014
期刊：
影响因子：
3.4
通讯作者：
Weiping Min
中科院分区：
文献类型：
--
作者：
Qing Li;Liu Liu;Yanling Liu;Hui Zhou;Z. Yang;K. Yuan;Weiping Min
摘要
环氧合酶-2基因多态性与乳腺癌的相关性已被广泛研究，但结果仍存在争议。因此，本荟萃分析旨在研究COX-2单核苷酸多态(rs5275、rs20417、rs689466、rs5277、rs2206593)与乳腺癌风险的关系。数据来源于PubMed、Embase和中国国家知识基础设施。采用95%可信区间(CI)的汇总优势比(OR)来评估两者之间的关系。同时进行异质性检验、敏感性分析和发表偏倚检验。本研究共17篇文章，包含19项研究。14项病例对照研究涉及15,007例乳腺癌患者和20,005名对照，涉及rs5275基因多态性；8项病例对照研究涉及rs20417基因多态性，涉及10,216例病例和12,839名对照。另外3个多态性(rs689466、rs2206593、rs5277)分别在5个、3个和3个研究中被研究。与G等位基因相比，COX-2-rs20417 CC等位基因与乳腺癌发病风险显著相关[CC与GG的OR值分别为1.231(1.050~1.444)，P0.01；1.223(1.045~1.432)，P0.01]。此外，按种族划分的亚组分析结果表明，C等位基因显著增加了亚洲人患乳腺癌的风险[GC为1.459(1.182-1.802)vs GG，C携带者为1.472(1.201-1.805)vs GG]。然而，在所有比较模式中未发现rs5275、rs689466、rs5277和rs2206593的关联。这一荟萃分析表明，COX-2rs20417基因多态性与乳腺癌的遗传易感性有关。相反，COX-2rs5275、rs689466、rs2206593和rs5277基因多态可能与乳腺癌的风险无关。
Abstract
The correlationship between COX-2 gene polymorphisms and breast cancer has been wildly studied, but the results remain controversial. Hence, the present meta-analysis aimed to investigate the association between COX-2 SNPs (rs5275, rs20417, rs689466, rs5277, rs2206593) and risk of breast cancer. Data were collected from PubMed, Embase and China National Knowledge Infrastructure. Summary odds ratio (OR) with 95 % confidence interval (CI) was applied to assess the relationship. Heterogeneity test, sensitivity analysis and publication bias test were also performed. There were 17 articles that contained 19 studies in this research. Fourteen case–control studies with 15,007 breast cancer cases and 20,005 controls were concerning rs5275 polymorphism, and 8 case–control studies with 10,216 cases and 12,839 controls were about rs20417 polymorphism. Other three polymorphisms (rs689466, rs2206593, rs5277) were studied in 5, 3 and 3 studies, respectively. COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050–1.444) for CC vs. GG, P = 0.01, 1.223 (1.045–1.432) for CC vs. G carrier, P = 0.01]. Furthermore, the results of the subgroup analysis by ethnicity suggested that C allele significantly contributed to the risk of breast cancer for Asians [1.459 (1.182–1.802) for GC vs. GG, 1.472 (1.201–1.805) for C carrier vs. GG]. However, no association was found for rs5275, rs689466, rs5277 and rs2206593 in all comparison modes. This meta-analysis indicated that the COX-2 rs20417 polymorphism contributed to genetic susceptibility of breast cancer. In contrast, COX-2 rs5275, rs689466, rs2206593 and rs5277 polymorphisms might be not associated with the risk of breast cancer.
影响因子：
11.2
作者：
Xin-hua Liu;D. Rose
通讯作者：
Xin-hua Liu;D. Rose