PRENATAL ORIGIN OF SCHIZOPHRENIA IN A SUBGROUP OF DISCORDANT MONOZYGOTIC TWINS
PRENATAL ORIGIN OF SCHIZOPHRENIA IN A SUBGROUP OF DISCORDANT MONOZYGOTIC TWINS
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DOI：
10.1093/schbul/20.3.423
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发表时间：
1994-01-01
影响因子：
6.6
通讯作者：
GOTTESMAN, II
中科院分区：
文献类型：
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作者：
TORREY, EF;TAYLOR, EH;GOTTESMAN, II
神经病理学、产科和流行病学证据越来越多地表明，一些成人发病的精神分裂症病例有产前或新生儿的病因。我们评估了23对精神分裂症不一致的同卵双胞胎的发育历史，以确定他们何时在运动技能或异常行为上开始明显和永久地彼此偏离。后来患上精神分裂症的双胞胎中有7人（30%）在5岁时就与双胞胎永久不同了。早期分化组在双胞胎内效应的多变量检验（p = 0.002）、生理异常评分（p = 0.01）、指脊总数（p = 0.001）、精神病家族史（p = 0.004）、严重围产期并发症或低出生体重（p = 0.05）等单变量检验中与其他组存在差异。结论是，一些成人发病的精神分裂症病例与产前事件有关，其中可能包括神经发育异常或特定的损害，如缺氧或感染性病原体。
Neuropathological, obstetrical, and epidemiological evidence increasingly suggest that some cases of adult-onset schizophrenia have prenatal or neonatal etiological roots. We evaluated the developmental histories of 23 monozygotic twin pairs discordant for schizophrenia to determine when they markedly and permanently began diverging from each other in motor skills or unusual behavior. Seven of the twins (30%) who later developed schizophrenia had become permanently different from their cotwins by age 5 years. The early divergence group differed from the others by multivariate tests (p = 0.002) for within-twin pair effects and by univariate tests for physical anomaly scores (p = 0.01), total finger ridge counts (p = 0.001), family history of psychosis (p = 0.004), and serious perinatal complications or low birth weight (p = 0.05). It is concluded that some cases of adult-onset schizophrenia are associated with prenatal events, which may include neurodevelopmental abnormalities or specific insults such as anoxia or infectious agents.