Structural insights into how 5-hydroxymethylation influences transcription factor binding
Structural insights into how 5-hydroxymethylation influences transcription factor binding
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DOI：
10.1039/c3cc48151d
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Schofield, Christopher J.
中科院分区：
文献类型：
--
作者：
Lercher, Lukas;McDonough, Michael A.;Schofield, Christopher J.
具有胞嘧啶、甲基胞嘧啶和羟甲基胞嘧啶碱基的Dickerson-Drew双链体的转录因子结合和高分辨率晶体学研究（1.3埃）提供了C-5胞嘧啶修饰可以通过对DNA转录因子相互作用的上下文依赖性效应来调节转录的证据。
Transcription factor binding and high resolution crystallographic studies (1.3 angstrom) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.