Spirocyclic Acylphloroglucinol Derivatives from Hypericum beanii
Spirocyclic Acylphloroglucinol Derivatives from Hypericum beanii
复制标题
金丝桃的螺环酰基间苯三酚衍生物
DOI：
10.1248/cpb.59.1250
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发表时间：
2011-10-01
影响因子：
1.7
通讯作者：
Xu, Gang
中科院分区：
文献类型：
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作者：
Chen, Xuan-Qin;Li, Yan;Xu, Gang
从贯叶连翘甲醇提取物中分离得到4个新的具有6/6/5螺环骨架的酰基间苯三酚，分别为高豆醇A-D(1-4)和16个已知化合物。通过光谱分析和X-射线衍射法确定了它们的结构。金丝桃醇A-C是三个不同的立体异构体，仅在C-4和C-13的相对构型上不同，通过核奥伊尔豪泽效应谱(NOESY)数据结合金丝桃醇A(1)的单X-射线分析来区分它们。测定了金丝桃醇A D对癌细胞株SK-BR-3、HL-60、SMMC-7721、PANC-1、MCF-7和K562的细胞毒活性。
Four new acylphloroglucinols with an unusual 6/6/5 spirocyclic skeleton, hyperbeanols A-D (1-4), were isolated from the methanol extract of Hypericum beanii along with 16 known compounds. Their structures were established on the basis of spectroscopic and X-ray diffraction analysis. Hyperbeanols A-C were three stereoisomers different only at the relative configuration of C-4 and C-13, which were distinguished by the nuclear Oyerhauser effect spectroscopy (NOESY) spectroscopic data in combination with the single X-ray analysis of hyperbeanol A (1). The cytotoxic activity of hyperbeanols A D against the cancer cell lines SK-BR-3, HL-60, SMMC-7721, PANC-1, MCF-7, and K562 was also evaluated.