SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise.
SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise.
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DOI:
10.3390/microorganisms9071389
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发表时间:
2021-06-27
期刊:
影响因子:
4.5
通讯作者:
Dittmann M
中科院分区:
文献类型:
--
作者:
Duerr R;Crosse KM;Valero-Jimenez AM;Dittmann M
SARS-CoV-2 and HIV are zoonotic viruses that rapidly reached pandemic scale, causing global losses and fear. The COVID-19 and AIDS pandemics ignited massive efforts worldwide to develop antiviral strategies and characterize viral architectures, biological and immunological properties, and clinical outcomes. Although both viruses have a comparable appearance as enveloped viruses with positive-stranded RNA and envelope spikes mediating cellular entry, the entry process, downstream biological and immunological pathways, clinical outcomes, and disease courses are strikingly different. This review provides a systemic comparison of both viruses’ structural and functional characteristics, delineating their distinct strategies for efficient spread.
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发表时间:
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期刊:
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