Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite
Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite
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DOI：
10.1530/eje-07-0768
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发表时间：
2008-04-01
影响因子：
5.8
通讯作者：
Kangawa, Kenji
中科院分区：
文献类型：
--
作者：
Akamizu, Takashi;Iwakura, Hiroshi;Kangawa, Kenji
背景资料：Ghrelin在调节食物摄入（FI）中起重要作用，这使其成为治疗厌食症的强有力的候选药物。目的：我们试图评估由功能性疾病（如功能性消化不良（FD））引起的厌食症患者对重复Ghrelin给药的临床反应。本研究纳入的受试者为1）诊断为功能性厌食症，包括FD和除神经性厌食症外的其他进食障碍; 2）偏瘦（体重指数（BMI）< 22 kg/m2）; 3）FI降低。受试者接受胃饥饿素（3 μ g/kg）静脉输注，每天两次（早餐和晚餐前），每次30分钟，持续2周。我们调查了胃饥饿素管理FI，食欲，激素和代谢parameters.Results的影响：6例FD患者参加了这项研究。与治疗完成前后的水平相比，Ghrelin给药倾向于增加每日FI，但作为本研究主要终点的这种差异未达到统计学显著性（P=0.084）。饥饿感在滴注结束时显著升高（P < 0.0001）。没有严重的不良反应observed.Conclusions：这些结果表明，胃饥饿素管理是安全的，这种治疗方法对FD患者的食欲有刺激作用。进一步的研究是必要的，以确认生长激素释放肽治疗厌食症相关疾病的疗效。
Background: Ghrelin plays a major role in the regulation of food intake (FI), which makes it a strong candidate for the treatment of anorexia.Objective: We attempted to evaluate the clinical response to repeated ghrelin administration in patients with anorexia caused by functional disorders, such as functional dyspepsia (FD).Subjects and methods: Subjects included in this study were those who 1) were diagnosed with functional anorexia, including FD and other eating disorders with the exception of anorexia nervosa; 2) were lean (body mass index (BMI) < 22 kg/m(2)); and 3) exhibited decreased FI. Subjects received an i.v. infusion of ghrelin (3 mu g/kg) for 30 min twice a day (before breakfast and dinner) for 2 weeks. We investigated the effects of ghrelin administration on FI, appetite, hormones, and metabolic parameters.Results: Six patients with FD were enrolled in this study. Ghrelin administration tended to increase daily FI in comparison with levels before and after completion of treatment, but this difference that was the primary endpoint of this study did not reach statistical significance (P=0.084). Hunger sensation was significantly elevated at the end of drip infusion (P < 0.0001). No severe adverse effects were observed.Conclusions: These results suggest that ghrelin administration is safe and that this treatment has stimulatory effects on appetite in patients with FD. Further studies are necessary to confirm the efficacy of ghrelin treatment for anorexia-related disorders.