Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa
Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa
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DOI：
10.1007/978-3-319-17121-0_39
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Pennesi, Mark E.
中科院分区：
文献类型：
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作者：
Gale, Michael J.;Feng, Shu;Pennesi, Mark E.
本研究的目的是将泛光照明的自适应光学(AO)图像与彩色眼底、眼底自发荧光(FAF)和光谱域光学相干断层扫描(SD-OCT)图像相关联。我们使用来自Imagine Eyes(法国奥赛)的rtx1(TM)泛光照明型声光摄像机对39名被诊断为RP的受试者进行了成像。我们观察到Faf上的超自体荧光变化、SD-OCT上交叉区(IZ)的破坏和AO上反射锥轮廓的丢失之间存在相关性。在AO上可以看到四种主要的锥体反射率模式：假定健康的锥体马赛克、低反射模糊的锥状结构、高频散乱的高反射点和低频率的低反射点。这些区域与SD-OCT和Faf观察到的视锥感光细胞退行性变的进行性阶段相关。这些结果有助于解释泛光灯照射下RP受试者的面部图像。然而，对于什么才是真正的锥体，特别是在退行性变的区域，仍然存在重大的模糊。随着技术的进一步完善，泛光照射的声学成像有可能为视网膜变性患者提供快速、标准化、纵向和低成本的成像。
The purpose of this study was to correlate features on flood-illuminated adaptive optics (AO) images with color fundus, fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) images in patients with retinitis pigmentosa (RP). We imaged 39 subjects diagnosed with RP using the rtx1 (TM) flood-illuminated AO camera from Imagine Eyes (Orsay, France). We observed a correlation between hyper-autofluoresence changes on FAF, disruption of the interdigitation zone (IZ) on SD-OCT and loss of reflective cone profiles on AO. Four main patterns of cone-reflectivity were seen on AO: presumed healthy cone mosaics, hypo-reflective blurred cone-like structures, higher frequency disorganized hyper-reflective spots, and lower frequency hypo-reflective spots. These regions were correlated to progressive phases of cone photoreceptor degeneration observed using SD-OCT and FAF. These results help provide interpretation of en face images obtained by flood-illuminated AO in subjects with RP. However, significant ambiguity remains as to what truly constitutes a cone, especially in areas of degeneration. With further refinements in technology, flood illuminated AO imaging has the potential to provide rapid, standardized, longitudinal and lower cost imaging in patients with retinal degeneration.