Self-Reproduction of Nanoparticles through Synergistic Self-Assembly.
Self-Reproduction of Nanoparticles through Synergistic Self-Assembly.
复制标题
通过协同自组装实现纳米粒子的自我复制。
作者：
K. Ikeda;M. Nakano
我们通过前体的化学连接和构建块的自组装描述了纳米尺寸颗粒（即纳米圆盘）的自我复制机制。连接反应在脂质双层表面加速，产物自发地与脂质分子组装成纳米盘。随着纳米盘数量的增加，纳米盘的快速增殖是通过预先存在的纳米盘和未反应材料之间的分子空间重排发生的，而不是前体的模板或复合物增强的连接。随后整合前体的表面增强连接过程使纳米颗粒成熟为预先存在的组装体的相同副本。我们的研究表明，协同自组装机制可能是异质多分子系统自我复制原理的基础。
We describe a self-reproduction mechanism of nanometer-sized particles (i.e., nanodiscs) through chemical ligation of the precursors and self-assembly of the building blocks. The ligation reaction was accelerated on lipid bilayer surfaces, and the products spontaneously assembled into nanodiscs with lipid molecules. With the increase in the number of nanodiscs, a rapid proliferation of the nanodiscs occurred through the spatial rearrangements of the molecules between the pre-existing nanodiscs and the unreacted materials, rather than template- or complex-enhanced ligation of the precursors. The subsequent process of surface-enhanced ligation of integrated precursors matured the nanoparticles into identical copies of the pre-existing assembly. Our study showed that the synergistic self-assembly mechanism probably underlie the self-replication principles for heterogeneous multimolecular systems.