Rhodopsin structure, function, and topography the Friedenwald lecture.
Rhodopsin structure, function, and topography the Friedenwald lecture.
复制标题
DOI：
--
复制
发表时间：
2001
影响因子：
4.4
通讯作者：
P. Hargrave
中科院分区：
文献类型：
--
作者：
P. Hargrave
在过去的30年里，关于视紫红质结构和功能的知识的增加简直是惊人的。虽然Kühne早在19世纪70年代就研究了视紫红质的一些性质，但直到20世纪60年代末，对视紫红质的分子性质的表征仍然相当初级。目前，有关于多达100种脊椎动物视觉色素的完整氨基酸序列的信息，关于视紫红质在健康和疾病中的功能的丰富信息，以及分辨率为5？的视紫红质的三维结构。此外，对视紫红质结构和功能的了解使人们对整个类别的G蛋白相关受体的功能有了更深入的了解(综述见参考文献)。2和3)。
The increase in knowledge of rhodopsin structure and function has been nothing short of phenomenal over the past 30 years. Although some of rhodopsin’s properties had been investigated by Kühne as early as the 1870s, the characterization of rhodopsin’s molecular properties was still quite rudimentary into the late 1960s. Currently, there is information concerning the complete amino acid sequence of as many as 100 vertebrate visual pigments, a wealth of information about the function of rhodopsin in health and disease and a threedimensional structure of rhodopsin with a resolution of 5 Å. Moreover, the knowledge of rhodopsin structure and function has led to an appreciation for how the entire class of Gprotein–linked receptors may function (for reviews see Refs. 2 and 3).