Cholesterol among children of men with myocardial infarction.
Cholesterol among children of men with myocardial infarction.
复制标题
患有心肌梗塞的男性儿童中的胆固醇。
DOI：
10.1542/peds.58.2.211
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发表时间：
1976
期刊：
影响因子：
8
通讯作者：
S. Blumenthal
中科院分区：
文献类型：
--
作者：
C. Hennekens;M. Jesse;B. Klein;J. Gourley;S. Blumenthal
测定了39例早产儿心肌梗死患者的90名儿童和39名健康男性的86名儿童的血浆胆固醇水平。患病男性儿童的平均胆固醇水平(195.1 mg/100ml)高于健康男性儿童的平均胆固醇水平(176.6 mg/100ml)(P=0.009)。在1至21岁的9个年龄组中，每个年龄组的平均水平都较高(P=0.004)。在患病父亲的子女中，有16.7%的子女血药浓度高于230毫克/100毫升，而在健康父亲的子女中，有4.7%的子女血药浓度高于230毫克/100毫升，两者之比为3.6：1(P=0.01)。这些发现与儿童时期胆固醇水平升高提供了一种家族史预测冠心病的机制的假设是一致的。青春期胆固醇的下降，这一发现随着研究人群的不同而不同，在这两个受影响的健康男性的孩子中都可以证明。
Plasma cholesterol levels were obtained on 90 children of 39 men with premature myocardial infarction and 86 children of 39 healthy men. The mean cholesterol among children of affected men (195.1 mg/100 ml) was higher than among children of healthy men (176.6 mg/100 ml) (P equal to .009). Higher mean levels were demonstrable at each of nine age groups from 1 to 21 years(P equal to .004). Levels greater than 230 mg/100 ml were found in 16.7% of children of affected fathers and 4.7% of children of healthy fathers, a ratio of 3.6 to 1 (P equal to .01). These findings are compatible with the hypothesis that elevated childhood cholesterol level offers a mechanism whereby family history predicts coronary disease. A dip in cholesterol during adolescence, a finding that varies with population studied, was demonstratable among children of both affected healthy men.