Brain temperature and metabolic responses during umbilical cord occlusion in fetal sheep.
Brain temperature and metabolic responses during umbilical cord occlusion in fetal sheep.
复制标题
胎羊脐带闭塞期间的脑温度和代谢反应。
DOI：
10.1007/s004240050687
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Power,GG
中科院分区：
文献类型：
--
作者：
Kubonoya,K;Yoneyama,Y;Sawa,R;Araki,T;Power,GG
本研究的目的是比较脐带完全但间歇性闭塞后的核心体温和大脑温度。将热电偶探针放置在8只近足月胎羊的旁顶叶皮质、升主动脉和颈静脉以及母体降主动脉中。三天后，在初始控制期后，将脐带封闭5分钟，然后是30分钟的恢复期，并重复该循环4次。测量体温变化、血气、血糖、乳酸和腺苷。在第一个闭塞期，身体核心温度比对照组升高0.12°C，然后在脐带释放后下降到基线，并且这种模式在随后的闭塞中重复。然而，大脑温度并没有因为任何脊髓闭塞而升高。血浆腺苷增加2.4倍，在第一次闭塞，但不是在随后的闭塞，尽管持续模式的恒定的大脑温度，结果最大限度地减少腺苷的重要性，作为一个持续调节大脑代谢。我们的结论是，由于大脑产热减少和脑血流量增加，脑温度未能增加，这延迟了脑组织中腺苷5′-三磷酸储存的完全耗尽。
The purpose of this study was to compare core body and brain temperatures after complete but intermittent occlusions of the umbilical cord. Thermocouple probes were placed in the parasagittal parietal cortex, ascending aorta, and jugular vein of eight near-term fetal sheep and in the maternal descending aorta. Three days later, after an initial control period, the umbilical cord was occluded for 5 min, followed by a 30-min recovery period, and this cycle was repeated 4 times. Temperature changes, blood gases, and plasma glucose, lactate and adenosine were measured. In the first occlusion period, body core temperature increased 0.12°C over control, and then declined to baseline after cord release, and this pattern was repeated with subsequent occlusions. Brain temperature, however, did not increase in response to any of the cord occlusions. Plasma adenosine increased 2.4-fold during the first occlusion, but not during subsequent occlusions, despite a continuing pattern of constant brain temperature, a result which minimizes adenosine’s importance as a continuing regulator of cerebral metabolism. We conclude that brain temperature fails to increase because of diminished heat production by the brain and increases in cerebral blood flow, responses which delay complete depletion of adenosine 5′-triphosphate stores in brain tissue.